|Feature type||allele||Associated gene||Dmel\tutl|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Pan-neuronal expression of the diffusible tutl[GH15753.Scer\UAS] isoform under the control of Scer\GAL4[elav-C155] produces Fas2-positive tracks that crisscross the midline. The same phenotype is produced upon expression in the midline, driven by Scer\GAL4[sim.PS]. Overexpression of tutl[AT02763.Scer\UAS] under the control of Scer\GAL4[sca-109-68], Scer\GAL4[how-24B] or Scer\GAL4[G14] produces excessive branching of the ISNd nerve, stalling of motor nerves, with some nerves, such as the transverse nerve, innervating muscles that are not their normal targets. Overexpression of tutl[AT02763.Scer\UAS] in a wild-type background using the retina-specific Scer\GAL4[GMR.PF] produces neuronal defects in that many retinal axons stall before reaching their targets and some sprout extra axonal processes that can invade the cortex. Pan-neuronal overexpression of tutl[AT02763.Scer\UAS] under the control of Scer\GAL4[elav-C155] promotes neuronal invasiveness, with some neuronal cell bodies invading the normally cell-free neuropil layer.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to rescue|
Post-mitotic neuronal expression of tutl[AT02763.Scer\UAS] under the control of either Scer\GAL4[sim.PS] or Scer\GAL4[elav-C155] fully rescues the midline crossing defects found in tutl[ex383] and tutl[ex383]/Df(2L)ed-dp mutants. Expression under the control of Scer\GAL4[repo] does no rescue the phenotype, indicating that expression near the midline is important for rescue. Post-mitotic neuronal expression of tutl[AT02763.Scer\UAS] under the control of Scer\GAL4[elav-C155] is sufficient to rescue the adult lethality found in tutl[ex383] mutants. Expression of tutl[AT02763.Scer\UAS] via Scer\GAL4[elav-C155] can reduce the motor axon projection defects found in tutl[ex383] homozygotes. Expression of either tutl[AT02763.Scer\UAS] driven by the pan-neuronal driver Scer\GAL4[elav-C155] rescues most aspects of tutl[k14703]/tutl[ex383] mutant eye defects.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|