Allele Dmel\tutl^{GH08133.Scer\UAS}

General Information
Symbol	Dmel\tutl^{GH08133.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0241907
Feature type	allele	Associated gene	Dmel\tutl

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Al-Anzi and Wyman, 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of tutl coding sequences corresponding to the GH08133 isoform. (Al-Anzi and Wyman, 2009)
Carried in construct	P{UAS-tutl.GH08133} (Al-Anzi and Wyman, 2009)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4^G14 (Al-Anzi and Wyman, 2009) neuroanatomy defective, with Scer\GAL4^GMR.PF (Al-Anzi and Wyman, 2009) neuroanatomy defective, with Scer\GAL4^how-24B (Al-Anzi and Wyman, 2009) neuroanatomy defective, with Scer\GAL4^sca-109-68 (Al-Anzi and Wyman, 2009)
Phenotype Manifest In
	intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^G14 (Al-Anzi and Wyman, 2009) intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^how-24B (Al-Anzi and Wyman, 2009) intersegmental nerve branch ISNd of A1-7, with Scer\GAL4^sca-109-68 (Al-Anzi and Wyman, 2009) optic lobe, with Scer\GAL4^GMR.PF (Al-Anzi and Wyman, 2009) transverse nerve, with Scer\GAL4^G14 (Al-Anzi and Wyman, 2009) transverse nerve, with Scer\GAL4^how-24B (Al-Anzi and Wyman, 2009) transverse nerve, with Scer\GAL4^sca-109-68 (Al-Anzi and Wyman, 2009)
Detailed Description
	Statement Reference Pan-neuronal expression of the membrane-bound tutl[GH08133.Scer\UAS] isoform under the control of Scer\GAL4[elav-C155] does not generate a phenotype. Overexpression of tutl[GH08133.Scer\UAS] under the control of Scer\GAL4[sca-109-68], Scer\GAL4[how-24B] or Scer\GAL4[G14] produces branching of the ISNd nerve, stalling of motor nerves, with some nerves, such as the transverse nerve, innervating muscles that are not their normal targets. Overexpression of tutl[GH08133.Scer\UAS] in a wild-type background using the retina-specific Scer\GAL4[GMR.PF] produces neuronal defects in that many retinal axons stall before reaching their targets and some sprout extra axonal processes. (Al-Anzi and Wyman, 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^elav-C155/tutl^{GH08133.Scer\UAS} rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) Scer\GAL4^elav-C155/tutl^{GH08133.Scer\UAS} rescues tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH08133.Scer\UAS}/Scer\GAL4^sim.PS rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH08133.Scer\UAS}/Scer\GAL4^sim.PS rescues tutl^ex383 (Al-Anzi and Wyman, 2009)
Fails to rescue	Scer\GAL4^repo/tutl^{GH08133.Scer\UAS} fails to rescue Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) Scer\GAL4^repo/tutl^{GH08133.Scer\UAS} fails to rescue tutl^ex383 (Al-Anzi and Wyman, 2009)
Comments	Post-mitotic neuronal expression of tutl[GH08133.Scer\UAS] under the control of either Scer\GAL4[sim.PS] or Scer\GAL4[elav-C155] fully rescues the midline crossing defects found in tutl[ex383] and tutl[ex383]/Df(2L)ed-dp mutants. Expression under the control of Scer\GAL4[repo] does not rescue the phenotype, indicating that expression near the midline is important for rescue. (Al-Anzi and Wyman, 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	tutl^{GH08133.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Al-Anzi and Wyman, 2009, Neural Dev. 4: 31 The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding. [FBrf0209104]

Allele Dmel\tutlGH08133.Scer\UAS

Allele Dmel\tutl^{GH08133.Scer\UAS}