|Feature type||allele||Associated gene||Dmel\orb2|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
|Phenotype Manifest In|
|Complementation & Rescue Data|
Expression of orb2[B.Scer\UAS] under the control of Scer\GAL4[fru-GAL4], Scer\GAL4[c747] or Scer\GAL4[Mef2.247] restores 24 hour memory in orb2[Δ]/orb2[ΔQ] transheterozygotes. Using the TARGET system (using Scer\GAL80[ts.alphaTub84B] to suppress Scer\GAL4 expression a certain points during development) to express orb2[B.Scer\UAS] (under the control of Scer\GAL4[Mef2.247]) in the mushroom bodiesfully rescues long-term memory in orb2[Δ]/orb2[ΔQ] mutants when these flies are raised and tested at 29[o]C, but not when they are raised and tested at 18[o]C. Long-term memory is also restored when flies are raised at 18[o]C and then shifted to 29[o]C immediately after eclosion, thereby providing orb2 function only in the adults. The reciprocal experiment, in which flies are raised at 29[O]C, but shifted to 18[o]C as adults, does not restore long-term memory. Flies that are shifted up to 29[o]C just 2 hours before training show normal long-term memory, whereas those that are shifted immediately after training have no long-term memory. Conversely, flies shifted down to 18[o]C immediately after training have normal long-term memory, whereas flies shifted down to 18[o]C 24 hours before training, but then shifted up to 29[o]C immediately after training, do not.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|