FB2025_01 , released February 20, 2025
Allele: Dmel\mid1a5
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General Information
Symbol
Dmel\mid1a5
Species
D. melanogaster
Name
FlyBase ID
FBal0241992
Feature type
allele
Associated gene
Dmel\mid
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Svendsen et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?144term.

(Svendsen et al., 2009)

Mutation truncates the protein just prior to the T-box domain.

(Svendsen et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,464,061..5,464,061 [+]
Nucleotide change:

C5464061T

Amino acid change:

Q144term | mid-PA; Q144term | mid-PB

Reported amino acid change:

?144term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Svendsen et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Df(2L)H15-x4, mid1a5 has visible | somatic clone phenotype

      (Svendsen et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Somatic double mutant clones of mid1a5 and Df(2L)H15-x4 in the leg imaginal disc cause the autonomous transformation of the wg-dependent peg-shaped row 1/8 bristles into lateral or dorsal rapier-like bristles. Similar cell-autonomous transformations are observed in the second leg tibia, in which the ventral apical bristle is lost in double mutant clones that span the distal tibia. In most of the double mutant clones, a large bristle similar to the dorsally located pre-apical bristle develop in place of the apical bristle. The apical bristle associated cluster of peg-shaped spur bristles are autonomously transformed to dorsal-like rapier-shaped bristles in mid1a5-Df(2L)H15-x4 clones. The sex combs and transverse rows of the first leg are also deleted in mid1a5-Df(2L)H15-x4 clones. Other ventral structures are either lost or disorganised within mid1a5-Df(2L)H15-x4 clones.

      (Svendsen et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (9)