FB2025_01 , released February 20, 2025
Allele: Dmel\enokHM05195
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General Information
Symbol
Dmel\enokHM05195
Species
D. melanogaster
Name
FlyBase ID
FBal0242114
Feature type
allele
Associated gene
Dmel\enok
Associated Insertion(s)
Carried in Construct
P{TRiP.HM05195}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.HM05195}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HM05195
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Combined expression of RNAi transgenes enokGD4037 and enokHM05195 under the control of Scer\GAL4bab1-Gal4 results in a significant decrease of female germline stem cell (GSC) numbers per germarium during a two week period after eclosion. Expression of the RNAi lines only at adulthood in temperature shift experiments using Scer\GAL80ts.αTub84B causes a similar gradual GSC loss.

      Expression of Scer\GAL4bab1-Gal4>enokHM05195 results in a progressive decline in germarium cap cell numbers compared with wild-type.

      (Xin et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of dppScer\UAS.cNa with enokGD4037 and enokHM05195 under the control of Scer\GAL4bab1-Gal4 and Scer\GAL80ts.αTub84B is unable to attenuate the decline in germline stem cell numbers.

      Co-expression of dallyScer\UAS.cJa with enokGD4037 and enokHM05195 under the control of Scer\GAL4bab1-Gal4 and Scer\GAL80ts.αTub84B is unable to attenuate the decline in germline stem cell numbers.

      (Xin et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      enokHM05195
      Name Synonyms
      Secondary FlyBase IDs
        References (3)