FlyBase Allele Report: Dmel\Cul1[HM05197]

General Information

Symbol

Dmel\Cul1^HM05197

Species

D. melanogaster

Name

FlyBase ID

FBal0242116

Feature type

allele

Associated gene

Dmel\Cul1

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05197}

Also Known As

UAS-cul1^RNAi, TRiP.HM05197, UAS-Cul1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05197}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05197

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Cul1^HM05197 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

(Ke et al., 2018)

Expressing Cul1^HM05197 under the combined control of Scer\GAL4^wor.PA and Scer\GAL80^ase.PU leads to supernumerary type II neuroblasts in the larval optic lobe.

(Komori et al., 2018)

Flies carrying clones expressing Cul1^HM05197 under the control of Scer\GAL4^Act.PU in the Johnston's organ display detached scolopidia phenotype.

(Li et al., 2016)

Expression of Cul1^HM05197 in somatic cyst cells under the control of any of Scer\GAL4^tj-NP1624, Scer\GAL4^A3.eya or Scer\GAL4^c784 (limited to a week from eclosion onwards using Scer\GAL80^ts.αTub84B) does not disrupt germline enclosure in testes, and cytoplasmic extensions from the cyst cells are clearly seen in the expected net-like pattern around the germline.

(Qian et al., 2015)

Expression of Cul1^HM05197 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of Cul1^HM05197 in the fat body under the control of Scer\GAL4^DcG has no effect on trehalose levels compared with controls.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference