FlyBase Allele Report: Dmel\EcR[JF02538]

General Information

Symbol

Dmel\EcR^JF02538

Species

D. melanogaster

Name

FlyBase ID

FBal0242218

Feature type

allele

Associated gene

Dmel\EcR

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02538}

Also Known As

UAS-EcR-RNAi, UAS-EcR^JF02538

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02538}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02538

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | P-stage, with Scer\GAL4^NP5130

(Zhang et al., 2024)

decreased cell growth rate | adult stage | male, with Scer\GAL4^esg.PU

(Sekar et al., 2023)

Phenotype Manifest In

enteroendocrine cell | P-stage | decreased number, with Scer\GAL4^NP5130

(Zhang et al., 2024)

intestinal stem cell | P-stage | increased number, with Scer\GAL4^NP5130

(Zhang et al., 2024)

male accessory gland secondary cell, with Scer\GAL4^esg.PU

(Sekar et al., 2023)

Detailed Description

Statement

Reference

Expression of EcR^JF02538 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

EcR^JF02538, Scer\GAL4^NP5130 has abnormal cell number | P-stage phenotype, suppressible by ase^UAS.cBa, Scer\GAL4^NP5130

(Zhang et al., 2024)

Suppressor of

Statement

Reference

Scer\GAL4^esg.PU, EcR^JF02538 is a suppressor of abnormal cell cycle | male | adult stage phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

NOT Suppressor of

Statement

Reference

EcR^JF02538, Scer\GAL4^esg.PU is a non-suppressor of abnormal cell cycle | adult stage | virgin male phenotype of CycE^UAS.cRa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

EcR^JF02538, Scer\GAL4^esg.PU is a non-suppressor of increased cell growth rate | adult stage | virgin male phenotype of CycE^UAS.cRa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

EcR^JF02538, Scer\GAL4^NP5130 has enteroendocrine cell | P-stage | decreased number phenotype, suppressible by ase^UAS.cBa, Scer\GAL4^NP5130

(Zhang et al., 2024)

Suppressor of

Statement

Reference

Scer\GAL4^esg.PU, EcR^JF02538 is a suppressor of male accessory gland secondary cell phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

NOT Suppressor of

Statement

Reference

EcR^JF02538, Scer\GAL4^esg.PU is a non-suppressor of male accessory gland secondary cell | virgin male phenotype of CycE^UAS.cRa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of EcR^JF02538 under the control of Scer\GAL4^mir-310.PL in Df(2R)Dm310s mutant background almost fully rescues the egg dorsal appendages defect characteristic for the Df(2R)Dm310s mutant eggs but it further exacerbates their reduced hatchability as well as the decreased male fertility (assayed under sperm-depletion conditions).

(Liufu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29374

y¹ v¹; P{TRiP.JF02538}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EcR^IR

(Zhang et al., 2015)

EcR^JF02538

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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