FB2025_01 , released February 20, 2025
Allele: Dmel\TkR99DJF02663
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General Information
Symbol
Dmel\TkR99DJF02663
Species
D. melanogaster
Name
FlyBase ID
FBal0242252
Feature type
allele
Associated gene
Dmel\TkR99D
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02663}
Also Known As
UAS-TkR99DRNAi, UAS-TkR99D-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02663}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02663
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of TkR99DJF02663 under the control of Scer\GAL4elav-C155 does not affect the expected increase in food consumption induced by dietary amino acids, as observed in controls.

      (Yang et al., 2018)

      Expression of TkR99DJF02663 under the control of Scer\GAL4elav.PU in adult females does not affect locomotor activity in fed conditions, compared to controls; like controls, locomotor activity is significantly increased under starvation conditions.

      (Yu et al., 2016)

      Knockdown of TkR99D in enterocrine cells, through expression of TkR99DJF02663 under the control of Scer\GAL4Myo31DF-NP0001 is sufficient to result in an increase in midgut lipid production and whole-body triglyceride storage.

      (Song et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of Pka-C1Scer\UAS.T:Zzzz\FLAG in enterocytes (under the control of Scer\GAL4Myo31DF-NP0001) is sufficient to reverse the increased intestinal lipid production and systemic triglyceride storage associated with TkR99D knockdown.

      Expression of SREBPJF01997 in enterocytes potently blocks the increase in midgut lipid level and systemic triglyceride storage associated with TkR99D knockdown.

      (Song et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Takr99DJF02663
      TkR99DJF02663
      Name Synonyms
      Secondary FlyBase IDs
        References (11)