FB2025_01 , released February 20, 2025
Allele: Dmel\Kap-α3JF02686
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General Information
Symbol
Dmel\Kap-α3JF02686
Species
D. melanogaster
Name
FlyBase ID
FBal0242274
Feature type
allele
Associated gene
Dmel\Kap-α3
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02686}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02686}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02686
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Kap-α3JF02686 under the control of Scer\GAL4GMR.PF does result in any obvious eye phenotypes compared to controls.

      (Sowa et al., 2018)

      Expression of Kap-α3JF02686 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.

      (Ugrankar et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3tr.Q78.UAS.Tag:HA under the control of Scer\GAL4GMR.PF are slightly improved by the co-expression of Kap-α3JF02686. The late-onset eye defects (i.e. disorganized ommatidia and tissue dissociation associated with the appearance of vacuoles) induced by the Scer\GAL4ninaE.PT-driven expression are also mildly improved by the co-expression of Kap-α3JF02686.

      The decreased adult locomotion and the decreased lifespan induced by the adulthood-only expression of Hsap\ATXN370Q.UAS under the control of Scer\GAL4elav.Switch.PO and RU-486 treatment are respectively fully and partially suppressed by the co-expression of Kap-α3JF02686.

      (Sowa et al., 2018)

      Co-expression of Kap-α3JF02686 suppresses the progressive retinal degeneration seen in fly eyes with Hsap\CACNA1AScer\UAS.αACT.Q70 driven by Scer\GAL4GMR.PU.

      (Tsou et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Kap-α3JF02686
      Name Synonyms
      Secondary FlyBase IDs
        References (7)