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General Information
Symbol
Dmel\Kap-α3JF02686
Species
D. melanogaster
Name
FlyBase ID
FBal0242274
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The expression of Kap-α3JF02686 under the control of Scer\GAL4GMR.PF does result in any obvious eye phenotypes compared to controls.
Expression of Kap-α3JF02686 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3tr.Q78.UAS.Tag:HA under the control of Scer\GAL4GMR.PF are slightly improved by the co-expression of Kap-α3JF02686. The late-onset eye defects (i.e. disorganized ommatidia and tissue dissociation associated with the appearance of vacuoles) induced by the Scer\GAL4ninaE.PT-driven expression are also mildly improved by the co-expression of Kap-α3JF02686. The decreased adult locomotion and the decreased lifespan induced by the adulthood-only expression of Hsap\ATXN370Q.UAS under the control of Scer\GAL4elav.Switch.PO and RU-486 treatment are respectively fully and partially suppressed by the co-expression of Kap-α3JF02686.
Co-expression of Kap-α3JF02686 suppresses the progressive retinal degeneration seen in fly eyes with Hsap\CACNA1AScer\UAS.αACT.Q70 driven by Scer\GAL4GMR.PU.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Kap-α3JF02686
Name Synonyms
Secondary FlyBase IDs
    References (5)