FlyBase Allele Report: Dmel\U2af50[JF02693]

General Information

Symbol

Dmel\U2af50^JF02693

Species

D. melanogaster

Name

FlyBase ID

FBal0242281

Feature type

allele

Associated gene

Dmel\U2af50

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02693}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02693}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02693

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental delay, dysmorphic facies, and brain anomalies

CEC

(Li et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of syndromic intellectual disability

is ameliorated by RpS19a^UAS.ORF

(Li et al., 2024)

is ameliorated by Iswi^{UAS.RR.Tag:FLAG,Tag:HA}

(Li et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage, with Scer\GAL4^ey-OK107

(Li et al., 2024)

abnormal heat stress response | adult stage, with Scer\GAL4^Toll-6-D42

(Li et al., 2024)

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Li et al., 2024)

abnormal starvation stress response | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Tang et al., 2018)

decreased occurrence of cell division | larval stage, with Scer\GAL4^elav.PU

(Li et al., 2024)

decreased size | larval stage, with Scer\GAL4^elav.PU

(Li et al., 2024)

decreased size | larval stage, with Scer\GAL4^ey-OK107

(Li et al., 2024)

lethal - all die before end of P-stage, with Scer\GAL4^elav.PU

(Li et al., 2024)

paralytic | adult stage, with Scer\GAL4^Toll-6-D42

(Li et al., 2024)

short lived, with Scer\GAL4^elav.PU

(Li et al., 2024)

viable, with Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Phenotype Manifest In

autophagosome | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

dendrite | larval stage, with Scer\GAL4^ppk.PG

(Li et al., 2024)

embryonic/larval fat body | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

embryonic/larval sensory neuron | larval stage, with Scer\GAL4^ppk.PG

(Li et al., 2024)

larval brain | larval stage, with Scer\GAL4^elav.PU

(Li et al., 2024)

lobe system of larval mushroom body | larval stage, with Scer\GAL4^elav.PU

(Li et al., 2024)

medial lobe of larval mushroom body, with Scer\GAL4^ey-OK107

(Li et al., 2024)

Detailed Description

Statement

Reference

Larval fat body clones expressing U2af50^JF02693 under the control of Scer\GAL4^Act.PU show impaired induction of autophagosomes (identified as mCherry-Atg8 puncta) in response to starvation.

(Tang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, non-enhanceable by CG13287^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased occurrence of cell division | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased occurrence of cell division | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased occurrence of cell division | larval stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, suppressible | partially by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has abnormal heat stress response | adult stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has paralytic | adult stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\U2AF2^R150C.UAS, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has paralytic | adult stage phenotype, suppressible | partially by Hsap\U2AF2^R150C.UAS, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\U2AF2^R149W.UAS, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^Toll-6-D42, U2af50^JF02693 has paralytic | adult stage phenotype, suppressible | partially by Hsap\U2AF2^R149W.UAS, Scer\GAL4^Toll-6-D42

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has abnormal neuroanatomy | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has abnormal neuroanatomy | larval stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has abnormal neuroanatomy | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, suppressible by Iswi^{UAS.RR.Tag:FLAG,Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, suppressible | partially by RpS19a^UAS.ORF, Scer\GAL4^elav.PU

(Li et al., 2024)

U2af50^JF02693 has decreased size | larval stage phenotype, suppressible | partially by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has lethal - all die before end of P-stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has lethal - all die before end of P-stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has lethal - all die before end of P-stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has decreased size | larval stage phenotype, non-suppressible by CG13287^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Other

Statement

Reference

Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU, U2af50^JF02693 has partially lethal - majority die phenotype

(Li et al., 2024)

Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU, U2af50^JF02693 has partially lethal - majority die phenotype

(Li et al., 2024)

Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU, U2af50^JF02693 has partially lethal - majority live phenotype

(Li et al., 2024)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-enhanceable by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-enhanceable by RpS19a^UAS.ORF, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has lobe system of larval mushroom body | larval stage phenotype, non-enhanceable by CG13287^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-enhanceable by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has lobe system of larval mushroom body | larval stage phenotype, suppressible by Iswi^{UAS.RR.Tag:FLAG,Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has medial lobe of larval mushroom body | larval stage phenotype, suppressible | partially by RpS19a^UAS.ORF, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has larval brain | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has larval brain | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has larval brain | larval stage phenotype, suppressible | partially by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has dendrite | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has dendrite | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has dendrite | larval stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has embryonic/larval sensory neuron | larval stage phenotype, suppressible by Hsap\U2AF2^UAS.cLa, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has embryonic/larval sensory neuron | larval stage phenotype, suppressible by Hsap\U2AF2^R149W.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^ppk.PG, U2af50^JF02693 has embryonic/larval sensory neuron | larval stage phenotype, suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^ppk.PG

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, suppressible | partially by Hsap\U2AF2^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, suppressible | partially by Hsap\U2AF2^R149W.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

U2af50^JF02693 has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, U2af50^JF02693 has lobe system of larval mushroom body | larval stage phenotype, non-suppressible by CG13287^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-suppressible by RpS19a^UAS.ORF, Scer\GAL4^elav.PU

(Li et al., 2024)

Scer\GAL4^elav.PU, U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-suppressible by Hsap\U2AF2^R150C.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

U2af50^JF02693 has vertical lobe of larval mushroom body | larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27542

y¹ v¹; P{TRiP.JF02693}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

U2af50^JF02693

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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