FlyBase Allele Report: Dmel\Atg7[JF02787]

General Information

Symbol

Dmel\Atg7^JF02787

Species

D. melanogaster

Name

FlyBase ID

FBal0242369

Feature type

allele

Associated gene

Dmel\Atg7

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02787}

Also Known As

UAS-ATG7 RNAi, Atg7 RNAi, Atg7-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02787}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02787

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^695.UAS

(Zhuang et al., 2020)

ameliorates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^alrm.PD

(Damulewicz et al., 2022)

abnormal neuroanatomy | adult stage, with Scer\GAL4^moody.SPG

(Damulewicz et al., 2022)

abnormal neuroanatomy | adult stage, with Scer\GAL4^repo.PU

(Damulewicz et al., 2022)

abnormal sleep | adult stage, with Scer\GAL4^alrm.PD

(Damulewicz et al., 2022)

abnormal sleep | adult stage, with Scer\GAL4^moody.SPG

(Damulewicz et al., 2022)

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

(Xu et al., 2015)

decreased size | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

increased sleep | adult stage, with Scer\GAL4^alrm.PD

(Damulewicz et al., 2022)

increased sleep | adult stage, with Scer\GAL4^moody.SPG

(Damulewicz et al., 2022)

increased sleep | adult stage, with Scer\GAL4^repo.PU

(Damulewicz et al., 2022)

visible | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Atg7^JF02787 RNAi under the control of Scer\GAL4^phm.PO leads to massive accumulation of lipid droplets in the prothoracic gland cells of third instar larvae.

(Danielsen et al., 2016)

Expression of Atg7^JF02787 under the control of Scer\GAL4^{Myo31DF-NP0001} does not lead to any defects in midgut degradation after pupariation, with no significant difference in the size of the gastric caeca 4 hrs after puparium formation, or in autophagy levels 2 hrs after puparium formation.

Expression of Atg7^JF02787 under the control of Scer\GAL4^cg.PU results in a decrease in starvation-induced autophagy in the larval fat body, as compared to controls.

(Xu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Atg7^JF02787, Scer\GAL4^bbg-C96 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Suppressor of

Statement

Reference

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of abnormal heat stress response | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of paralytic | adult stage | heat sensitive phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of visible | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Atg7^JF02787, Scer\GAL4^bbg-C96 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Suppressor of

Statement

Reference

Atg7^JF02787, Scer\GAL4^elav.PU is a suppressor of wing phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also co-expressing Atg7^JF02787.

(Kwon et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27707

y¹ v¹; P{TRiP.JF02787}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Atg7^JF02787

(Billes et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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