FB2025_01 , released February 20, 2025
Allele: Dmel\Pdk1JF02807
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General Information
Symbol
Dmel\Pdk1JF02807
Species
D. melanogaster
Name
FlyBase ID
FBal0242387
Feature type
allele
Associated gene
Dmel\Pdk1
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02807}
Also Known As
Pdk1 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02807}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02807
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Pdk1JF02807 under the control of Scer\GAL4slbo.2.6 leads to border cell migration failure or delay in all egg chambers, but does not have a major effect on border cell cluster integrity.

      (Raza et al., 2019)

      Expression of Pdk1JF02807 under the control of Scer\GAL4Act5C.Switch.PR (kept on a RU486-supplemented food to activate expression) leads to prolonged adult lifespan in females but not in males compared to RU486-unfed controls.

      (Danilov et al., 2015)

      Expression of Pdk1JF02807 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.

      (Ugrankar et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Pdk1JF02807, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pdk1JF02807
      Pk61CJF02807
      Name Synonyms
      Secondary FlyBase IDs
        References (12)