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General Information
Symbol
Dmel\Rab11JF02812
Species
D. melanogaster
Name
FlyBase ID
FBal0242392
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rab11RNAi, Rab11 RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Rab11JF02812 under the control of CtxGlia-SplitGal4 (Hsim\VP16AD.nrv2 and Scer\GAL4DBD.wrapper.932i) leads to an altered cortex glial morphology in third instar larvae when compared to controls.

Animals expressing Rab11JF02812 under the control of Scer\GAL4grh.D4 are lethal, show defects in larval dorsal trunk elongation (resulting in internalization of posterior spiracles into the body cavity) and the larvae are smaller than age-matched controls.

Expression of Rab11JF02812 under the control of Scer\GAL4tj-NP1624 results in abolished formation of stalk and monolayered epithelium and in follicle cells of germaria and early egg chambers.

Third larval instar adipocytes expressing Rab11JF02812 under the control of Scer\GAL4SPARC-MI00329-GAL4 show a significant decrease in both plasma membrane depth and sinuosity compared to control cells.

Expression of Rab11JF02812 in secondary cells under the control of Scer\GAL4dsx.KI reduces exosome secretion into the accessory gland lumen compared to controls.

Expression of Rab11JF02812 under the control of Scer\GAL4esg-NP5130, Scer\GAL4Dl-05151-G or Scer\GAL4Myo31DF-NP0001, but not under the control of Scer\GAL4Su(H).GBE, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in significantly increased numbers of mitotic cells in the midgut, as compared to controls. Expression of Rab11JF02812 under the control of Scer\GAL4Myo31DF-NP0001 cell non-autonomously leads to an increased number of cells in the intestinal stem cell-enteroblast nests, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rab11JF02812
Name Synonyms
Secondary FlyBase IDs
    References (17)