FlyBase Allele Report: Dmel\Rab11[JF02812]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Rab11^JF02812

General Information

Symbol

Dmel\Rab11^JF02812

Species

D. melanogaster

Name

FlyBase ID

FBal0242392

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02812}

Also Known As

Rab11 RNAi, rab11^RNAi, UAS-Rab11^RNAi, UAS-Rab11-RNAi

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02812}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of inflammatory bowel disease

CEA

(Yu et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

abnormal neuroanatomy | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

abnormal neurophysiology | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

decreased body size | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

increased cell number | adult stage | cell non-autonomous, with Scer\GAL4^NP0001

(Yu et al., 2014)

increased occurrence of cell division | adult stage, with Scer\GAL4^{Delta-05151-G}

(Yu et al., 2014)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

(Yu et al., 2014)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Yu et al., 2014)

lethal, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

visible | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

Phenotype Manifest In

adult midgut | adult stage, with Scer\GAL4^{Delta-05151-G}

(Yu et al., 2014)

adult midgut | adult stage, with Scer\GAL4^NP0001

(Yu et al., 2014)

adult midgut | adult stage, with Scer\GAL4^NP5130

(Yu et al., 2014)

egg chamber, with Scer\GAL4^NP1624

(Woichansky et al., 2016)

embryonic/larval cell body glial cell | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

embryonic/larval posterior spiracle | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

embryonic/larval tracheal dorsal trunk | first instar larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

enteroblast | adult stage | cell non-autonomous, with Scer\GAL4^NP0001

(Yu et al., 2014)

extracellular exosome, with Scer\GAL4^dsx.KI

(Corrigan et al., 2014)

extracellular vesicle | decreased number, with Scer\GAL4^elav.PU

(Kang et al., 2024)

follicle cell, with Scer\GAL4^NP1624

(Woichansky et al., 2016)

germarium, with Scer\GAL4^NP1624

(Woichansky et al., 2016)

intestinal stem cell | adult stage | cell non-autonomous, with Scer\GAL4^NP0001

(Yu et al., 2014)

male accessory gland secondary cell, with Scer\GAL4^dsx.KI

(Corrigan et al., 2014)

NMJ bouton | increased number | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

plasma membrane, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

presynaptic active zone | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

stalk follicle cell, with Scer\GAL4^NP1624

(Woichansky et al., 2016)

type I bouton | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

Detailed Description

Statement

Reference

Expression of Rab11^JF02812 under the control of CtxGlia-SplitGal4 (Hsim\VP16^AD.nrv2 and Scer\GAL4^{DBD.wrapper.932i}) leads to an altered cortex glial morphology in third instar larvae when compared to controls.

(Coutinho-Budd et al., 2017)

Animals expressing Rab11^JF02812 under the control of Scer\GAL4^grh.D4 are lethal, show defects in larval dorsal trunk elongation (resulting in internalization of posterior spiracles into the body cavity) and the larvae are smaller than age-matched controls.

(Wingen et al., 2017)

Expression of Rab11^JF02812 under the control of Scer\GAL4^tj-NP1624 results in abolished formation of stalk and monolayered epithelium and in follicle cells of germaria and early egg chambers.

(Woichansky et al., 2016)

Third larval instar adipocytes expressing Rab11^JF02812 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} show a significant decrease in both plasma membrane depth and sinuosity compared to control cells.

(Zang et al., 2015)

Expression of Rab11^JF02812 in secondary cells under the control of Scer\GAL4^dsx.KI reduces exosome secretion into the accessory gland lumen compared to controls.

(Corrigan et al., 2014)

Expression of Rab11^JF02812 under the control of Scer\GAL4^esg-NP5130, Scer\GAL4^Dl-05151-G or Scer\GAL4^{Myo31DF-NP0001}, but not under the control of Scer\GAL4^Su(H).GBE, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in significantly increased numbers of mitotic cells in the midgut, as compared to controls. Expression of Rab11^JF02812 under the control of Scer\GAL4^{Myo31DF-NP0001} cell non-autonomously leads to an increased number of cells in the intestinal stem cell-enteroblast nests, as compared to controls.

(Yu et al., 2014)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^esg.PU, rho^UAS.cUa

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Atg1^GD7149, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^esg.PU, Syx17^JF01937

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Rab5^SN.FRT.UAS, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Rab7^GD11800, Scer\GAL4^esg.PU

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

Rab11^JF02812, Scer\GAL4^ptc.PU is a non-suppressor of lethal - all die before end of P-stage phenotype of Hsap\KIF5B::Hsap\RET^UAS.cDa, Scer\GAL4^ptc.PU

(Das and Cagan, 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rab11^JF02812, Scer\GAL4^Cg.PA is an enhancer of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Rab11^JF02812, Scer\GAL4^Cg.PA is an enhancer of endoplasmic reticulum | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Rab11^JF02812, Scer\GAL4^Cg.PA is an enhancer of nucleus | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Suppressor of

Statement

Reference

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium phenotype of Rab7^GD11800, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^esg.PU, rho^UAS.cUa

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of Atg1^GD7149, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of Scer\GAL4^esg.PU, Syx17^JF01937

(Zhang et al., 2019)

Rab11^JF02812, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of Rab5^SN.FRT.UAS, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

27730

y¹ v¹; P{TRiP.JF02812}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rab11^JF02812

Rab11ⁱ

(Zang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections