FlyBase Allele Report: Dmel\dl[JF02825]

General Information

Symbol

Dmel\dl^JF02825

Species

D. melanogaster

Name

FlyBase ID

FBal0242403

Feature type

allele

Associated gene

Dmel\dl

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02825}

Also Known As

UAS-dl^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02825}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02825

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of dl^JF02825 in muscle under the control of Scer\GAL4^Mef2.PU results in significant hyperglycaemia.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dl^JF02825/Scer\GAL4^repo.PU is a suppressor | partially of short lived phenotype of Scer\GAL4^repo.PU, Uuuu\Ub^{K0.UAS.6.Stop.Tag:HA}

(Blount et al., 2020)

dl^JF02825/Scer\GAL4^en.PU is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^en.PU is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^da.PU is a suppressor | partially of lethal phenotype of Scer\GAL4^da.PU, mad2^GD16427

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

dl^JF02825/Scer\GAL4^en.PU is a suppressor | partially of wing disc posterior compartment | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^en.PU is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^en.PU is a suppressor of hemocyte | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

dl^JF02825/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (and of Dicer-2, for efficient RNAi) leads to a significant increase in aneuploidy in the posterior compartment of the third instar larval wing disc, which is greatly suppressed by co-expressing dl^JF02825.

Expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (together with Dicer-2, for efficient RNAi) results in increased numbers of hemocytes on the surface of third instar larval wing discs, as compared to controls, which are suppressed by co-expressing dl^JF02825.

Under 30[o]C temperature conditions, the expression of mad2^GD16427 under the control of Scer\GAL4^da.PU induces lethality before adulthood, which is partially suppressed by the co-expression of dl^JF02825.

(Liu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27650

y¹ v¹; P{TRiP.JF02825}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dl^JF02825

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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