FB2021_01, released Feb 18, 2021

Allele: Dmel\Ptp69DJF03399

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General Information
Symbol
Dmel\Ptp69DJF03399
Species
D. melanogaster
Name
FlyBase ID
FBal0242570
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03399}
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Perkins et al., 2009)
in vitro construct - regulatory fusion
(Perkins et al., 2009)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.JF03399}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of an inverted repeat.

      (Perkins et al., 2009)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Ptp69D
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-JF03399
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The very slight decrease in total dendrite density in class IV dendritic arborizing (da) neurons characteristic for third instar larvae transheterozygous for LarCRISPR.3/LarMI03443-TG4.1 is strongly enhanced by expression of Ptp69DJF03399 under the Scer\GAL4Lar-MI03443-TG4.1 driver (which is inherent to the LarMI03443-TG4.1 allele), in addition the terminal dendrite density and terminal dendrite numbers are also significantly reduced. Larvae heterozygous for LarMI03443-TG4.1 and expressing Ptp69DJF03399 (under the Scer\GAL4Lar-MI03443-TG4.1) driver display strong reduction in the total and terminal dendrite density as well as terminal dendrite numbers in the class IV da neurons relative to controls, this phenotype is not further worsened by combination with LarCRISPR.3.

      (Poe et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp69DJF03399
      Name Synonyms
      Secondary FlyBase IDs
        References (2)