Allele Dmel\Mical^Scer\UAS.fl

General Information
Symbol	Dmel\Mical^Scer\UAS.fl	Species	D. melanogaster
Name		FlyBase ID	FBal0242678
Feature type	allele	Associated gene	Dmel\Mical

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kirilly et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of full-length Mical coding sequences. (Kirilly et al., 2009)
Carried in construct	P{UAS-Mical.fl} (Kirilly et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4²²¹ (Kirilly et al., 2009) neuroanatomy defective, with Scer\GAL4^ppk.1.9 (Kirilly et al., 2009)
Phenotype Manifest In
	dendrite, with Scer\GAL4²²¹ (Kirilly et al., 2009) dendrite, with Scer\GAL4^ppk.1.9 (Kirilly et al., 2009) dorsal multidendritic neuron ddaC, with Scer\GAL4²²¹ (Kirilly et al., 2009) dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9 (Kirilly et al., 2009)
Detailed Description
	Statement Reference Overexpression of Mical[Scer\UAS.fl] under the control of either Scer\GAL4[ppk.1.9] or Scer\GAL4[221] results in mild pruning of primary and secondary dendrites by 6 hours APF. (Kirilly et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Mical^Scer\UAS.fl, Scer\GAL4^109(2)80 is a suppressor \| partially of neuroanatomy defective phenotype of EcR^{B1-ΔC655.W650A.Scer\UAS}, Scer\GAL4^109(2)80 (Kirilly et al., 2009) Scer\GAL4^109(2)80/Mical^Scer\UAS.fl is a suppressor \| partially of neuroanatomy defective phenotype of Sox14^Δ13 (Kirilly et al., 2009)
Phenotype Manifest In
Suppressor of
Statement Reference Mical^Scer\UAS.fl, Scer\GAL4^109(2)80 is a suppressor \| partially of dendrite phenotype of EcR^{B1-ΔC655.W650A.Scer\UAS}, Scer\GAL4^109(2)80 (Kirilly et al., 2009) Mical^Scer\UAS.fl, Scer\GAL4^109(2)80 is a suppressor \| partially of dorsal multidendritic neuron ddaC phenotype of EcR^{B1-ΔC655.W650A.Scer\UAS}, Scer\GAL4^109(2)80 (Kirilly et al., 2009) Scer\GAL4^109(2)80/Mical^Scer\UAS.fl is a suppressor \| partially of dendrite phenotype of Sox14^Δ13 (Kirilly et al., 2009) Scer\GAL4^109(2)80/Mical^Scer\UAS.fl is a suppressor \| partially of dorsal multidendritic neuron ddaC phenotype of Sox14^Δ13 (Kirilly et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference Expression of Mical[Scer\UAS.fl] in ddaC neurons under the control of Scer\GAL4[109(2)80] in a Sox14[Δ13] homozygous background partially suppresses the excess dendritic arborization found in Sox14[Δ13] mutants. Co-expression of Mical[Scer\UAS.fl] with EcR[B1-ΔC655.W650A.Scer\UAS] in ddaC neurons under the control of Scer\GAL4[109(2)80] partially suppresses the excess dendritic arborization found upon expression of EcR[B1-ΔC655.W650A.Scer\UAS] alone in ddaC neurons under the control of Scer\GAL4[109(2)80]. (Kirilly et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^ppk.1.9/Mical^Scer\UAS.fl rescues Mical¹⁵²⁵⁶ (Kirilly et al., 2009) Scer\GAL4^ppk.1.9/Mical^Scer\UAS.fl rescues Mical¹⁵²⁵⁶/Df(3R)swp2^MICAL (Kirilly et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Mical^Scer\UAS.fl
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Kirilly et al., 2009, Nat. Neurosci. 12(12): 1497--1505 A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. [FBrf0209365]

Allele Dmel\MicalScer\UAS.fl

Allele Dmel\Mical^Scer\UAS.fl