Allele Dmel\Mical¹⁵²⁵⁶

General Information
Symbol	Dmel\Mical¹⁵²⁵⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0242680
Feature type	allele	Associated gene	Dmel\Mical

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Kirilly et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:5,845,502..5,845,502 na_change=C5845502T pr_change=Q535 \| Mical-PC; Q535 \| Mical-PH; Q535 \| Mical-PG; Q535 \| Mical-PD; Q535 \| Mical-PA; Q535 \| Mical-PB; Q535 \| Mical-PE; Q535 \| Mical-PF; Q535 \| Mical-PI; Q535 \| Mical-PK; Q535 \| Mical-PL; Q535 \| Mical-PM reported_pr_change=Q535@ comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. (Beuchle et al., 2007)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q535@. (Kirilly et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Kirilly et al., 2009) neuroanatomy defective (with Df(3R)swp2^MICAL) (Kirilly et al., 2009)
Phenotype Manifest In
	dendrite (Kirilly et al., 2009) dendrite (with Df(3R)swp2^MICAL) (Kirilly et al., 2009) dorsal multidendritic neuron ddaC (Kirilly et al., 2009) dorsal multidendritic neuron ddaC (with Df(3R)swp2^MICAL) (Kirilly et al., 2009)
Detailed Description
	Statement Reference Mical[15256] and Mical[15256]/Df(3R)swp2[MICAL] mutants exhibit a failure of dendrite severing in ddaC neurons by 18h APF. Mical[15256] ddaC neurons retain an average of 7.4 primary and secondary dendrites attached to the soma at 18h APF and 3 dendrites at 24h APF, indicating that the mutant neurons have a strong severing defect. The overall larval dendrite morphology of ddaC neurons in the wL3 larvae of Mical[15256] zygotic mutants is indistinguishable from that of wild-type ddaC neurons, as judged by the number of terminal dendrites. Mical[15256] ddaC MARCM clones show a severing defect in ddaC neurons. (Kirilly et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Mical¹⁵²⁵⁶ has neuroanatomy defective phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4²²¹ (Kirilly et al., 2009) Mical¹⁵²⁵⁶ has neuroanatomy defective phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4^ppk.1.9 (Kirilly et al., 2009)
Suppressor of
Statement Reference Mical¹⁵²⁵⁶ is a suppressor of neuroanatomy defective phenotype of Scer\GAL4²²¹, Sox14^fl.Scer\UAS (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is a suppressor of neuroanatomy defective phenotype of Scer\GAL4^ppk.1.9, Sox14^fl.Scer\UAS (Kirilly et al., 2009)
Phenotype Manifest In
Suppressed by
Statement Reference Mical¹⁵²⁵⁶ has dendrite phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4²²¹ (Kirilly et al., 2009) Mical¹⁵²⁵⁶ has dendrite phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4^ppk.1.9 (Kirilly et al., 2009) Mical¹⁵²⁵⁶ has dorsal multidendritic neuron ddaC phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4²²¹ (Kirilly et al., 2009) Mical¹⁵²⁵⁶ has dorsal multidendritic neuron ddaC phenotype, suppressible \| partially by Sox14^fl.Scer\UAS/Scer\GAL4^ppk.1.9 (Kirilly et al., 2009)
Suppressor of
Statement Reference Mical¹⁵²⁵⁶ is a suppressor of dendrite phenotype of Scer\GAL4²²¹, Sox14^fl.Scer\UAS (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is a suppressor of dendrite phenotype of Scer\GAL4^ppk.1.9, Sox14^fl.Scer\UAS (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is a suppressor of dorsal multidendritic neuron ddaC phenotype of Scer\GAL4²²¹, Sox14^fl.Scer\UAS (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is a suppressor of dorsal multidendritic neuron ddaC phenotype of Scer\GAL4^ppk.1.9, Sox14^fl.Scer\UAS (Kirilly et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference Overexpression of Sox14[fl.Scer\UAS] under the control of either Scer\GAL4[ppk.1.9] or Scer\GAL4[221] in a homozygous Mical[15256] background has a very mild pruning effect on primary and secondary dendrites by 6 hours APF. (Kirilly et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Mical¹⁵²⁵⁶/Df(3R)swp2^MICAL is rescued by Scer\GAL4^ppk.1.9/Mical^Scer\UAS.fl (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is rescued by Scer\GAL4^ppk.1.9/Mical^Scer\UAS.fl (Kirilly et al., 2009)
Not rescued by	Mical¹⁵²⁵⁶/Df(3R)swp2^MICAL is not rescued by Mical^{N-ter.Scer\UAS}/Scer\GAL4^ppk.1.9 (Kirilly et al., 2009) Mical¹⁵²⁵⁶ is not rescued by Mical^{N-ter.Scer\UAS}/Scer\GAL4^ppk.1.9 (Kirilly et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	l(3)15256 (Kirilly et al., 2009) Mical¹⁵²⁵⁶
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Kirilly et al., 2009, Nat. Neurosci. 12(12): 1497--1505 A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. [FBrf0209365] Beuchle et al., 2007, Mech. Dev. 124(5): 390--406 Drosophila MICAL regulates myofilament organization and synaptic structure. [FBrf0200539]

Allele Dmel\Mical15256

Allele Dmel\Mical¹⁵²⁵⁶