Allele Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC}

General Information
Symbol	Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC}	Species	H. sapiens
Name		FlyBase ID	FBal0242935
Feature type	allele	Associated gene	Hsap\ACSL4

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion, in vitro construct - site directed mutagenesis
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Zhang et al., 2009) in vitro construct - regulatory fusion (Zhang et al., 2009) in vitro construct - site directed mutagenesis (Zhang et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: R570S. (Zhang et al., 2009) Scer\UAS sequences drive expression of the long form of Hsap\ACSL4 containing a R570S mutation with a C-terminal 6x T:Hsap\MYC tag. (Zhang et al., 2009)
Carried in construct	P{UAS-ACSL4.L.R570S} (Zhang et al., 2009)
Tagged with	T:Hsap\MYC (Zhang et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
NOT Suppressor of
Statement Reference Scer\GAL4^tub.PU/Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} is a non-suppressor of lethal phenotype of Acsl¹/Acsl⁸ (Zhang et al., 2009) Scer\GAL4^tub.PU/Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} is a non-suppressor of lethal phenotype of Acsl⁰⁵⁸⁴⁷/Acsl⁸ (Zhang et al., 2009) Scer\GAL4^tub.PU/Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} is a non-suppressor of neuroanatomy defective \| third instar larval stage phenotype of Acsl⁸/Acsl^k10313 (Zhang et al., 2009)
Phenotype Manifest In
NOT Suppressor of
Statement Reference Scer\GAL4^tub.PU/Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} is a non-suppressor of embryonic/larval brain \| third instar larval stage phenotype of Acsl⁸/Acsl^k10313 (Zhang et al., 2009) Scer\GAL4^tub.PU/Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC} is a non-suppressor of phenotype of Acsl⁰⁵⁸⁴⁷/Acsl⁸ (Zhang et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of Hsap\ACSL4[R570S.Scer\UAS.L.T:Hsap\MYC] under the control of Scer\GAL4[tub] fails to rescue the lethality associated with the Acsl[8]/Acsl[1] and Acsl[8]/Acsl[05847] genotypes. Expression of Hsap\ACSL4[R570S.Scer\UAS.L.T:Hsap\MYC] under the control of Scer\GAL4[tub] fails to restore neutral lipid staining in Acsl[8]/Acsl[05847] wing discs. Expression of Hsap\ACSL4[R570S.Scer\UAS.L.T:Hsap\MYC] under the control of Scer\GAL4[tub] fails to restore well-ordered axon projection in the optic lamina of the third instar larval brain of Acsl[8]/Acsl[k10313] mutants. (Zhang et al., 2009)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	32329 y¹ w^*; P{UAS-ACSL4.L.R570S}2/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Zhang et al., 2009, Hum. Mol. Genet. 18(20): 3894--3905 Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain. [FBrf0209077]

Allele Hsap\ACSL4R570S.Scer\UAS.L.T:Hsap\MYC

Allele Hsap\ACSL4^{R570S.Scer\UAS.L.T:Hsap\MYC}