Allele Dmel\tll^Scer\UAS.cKa

General Information
Symbol	Dmel\tll^Scer\UAS.cKa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Kurusu	FlyBase ID	FBal0243000
Feature type	allele	Associated gene	Dmel\tll

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kurusu et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of tll. (Kurusu et al., 2009)
Carried in construct	P{UAS-tll.K} (Kurusu et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	cell cycle defective \| larval stage, with Scer\GAL4^{elav.Switch.PO} (Kurusu et al., 2009) cell cycle defective \| pupal stage, with Scer\GAL4^{elav.Switch.PO} (Kurusu et al., 2009)
Phenotype Manifest In
	brain \| larval stage, with Scer\GAL4^{elav.Switch.PO} (Kurusu et al., 2009) brain \| pupal stage, with Scer\GAL4^{elav.Switch.PO} (Kurusu et al., 2009)
Detailed Description
	Statement Reference Ectopic expression of tll[Scer\UAS.cKa] by Scer\GAL4[elav.Switch.PO] results in hyperplasia and supernumerary neuroblasts in the 3rd instar larval brain and the mid-pupal brain (40hr after puparium formation). (Kurusu et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa has cell cycle defective \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa (Kurusu et al., 2009)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^{elav.Switch.PO}, tll^Scer\UAS.cKa has brain \| larval stage phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/pros^Scer\UAS.cMa (Kurusu et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference Co-overexpression of pros[Scer\UAS.cMa] and tll[Scer\UAS.cKa] by Scer\GAL4[elav.Switch.PO] rescues the tll[Scer\UAS.cKa]-induced brain hyperplasia in third instar larvae. (Kurusu et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^elav-C155/tll^Scer\UAS.cKa rescues tll¹ (Kurusu et al., 2009)
Comments	Rescues the tll[1] mutant phenotype of 10.4 neurons per mushroom body clone to 108. (Kurusu et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	tll^Scer\UAS.cKa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Kurusu
Secondary FlyBase IDs

References ( 1 )
Research paper	Kurusu et al., 2009, Dev. Biol. 326(1): 224--236 A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain. [FBrf0207181]

Allele Dmel\tllScer\UAS.cKa

Allele Dmel\tll^Scer\UAS.cKa