Allele Dmel\Fmr1^S174F.EP3517

General Information
Symbol	Dmel\Fmr1^S174F.EP3517	Species	D. melanogaster
Name		FlyBase ID	FBal0243006
Feature type	allele	Associated gene	Dmel\Fmr1

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Reeve et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:5,935,594..5,935,594 (Reeve et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}Fmr1^EP3517 (Reeve et al., 2008)
Nature of the lesion	Statement Reference Amino acid replacement: S174F. (Reeve et al., 2008) Fmr1[S174F.EP3517] carries both the P{EP} insertion present in the progenitor allele and the amino acid replacement in the Fmr1 coding region. (Reeve et al., 2008)
Caused by insertion	P{EP}Fmr1^EP3517 (Reeve et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	viable, with Scer\GAL4^αTub84B.PL (Reeve et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Fmr1^S174F.EP3517, Scer\GAL4^elav.PU, Sra-1^Scer\UAS.cSa has neuroanatomy defective phenotype (Reeve et al., 2008)
Phenotype Manifest In
Other
Statement Reference Fmr1^S174F.EP3517, Scer\GAL4^elav.PU, Sra-1^Scer\UAS.cSa has neuromuscular junction phenotype (Reeve et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference Co-overexpression of Fmr1[S174F.EP3517] and Sra-1[Scer\UAS.cSa] using Scer\GAL4[elav.PU] results in a significant neuromuscular junction overgrowth phenotype. (Reeve et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: A mutation that suppresses the lethality caused when a Scer\GAL4 driver is used to overexpress Fmr1 from the P{EP}Fmr1[EP3517] insertion. (Reeve et al., 2008)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Fmr1^S174F.EP3517 S174F (Reeve et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Reeve et al., 2008, J. Neurosci. 28(12): 3221--3226 Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. [FBrf0204382]

Allele Dmel\Fmr1S174F.EP3517

Allele Dmel\Fmr1^S174F.EP3517