Allele Dmel\Mkk4^e01485

General Information
Symbol	Dmel\Mkk4^e01485	Species	D. melanogaster
Name		FlyBase ID	FBal0243039
Feature type	allele	Associated gene	Dmel\Mkk4

Map ( GBrowse )	Untitled Document
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:4,473,306..4,476,824 (Rallis et al., 2010)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	PBac{RB}Mkk4^e01485 (Rallis et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| somatic clone (Rallis et al., 2010)
Phenotype Manifest In
	axon \| somatic clone (Rallis et al., 2010) Kenyon cell \| somatic clone (Rallis et al., 2010)
Detailed Description
	Statement Reference Mkk4[e01485] neuroblast clones in mushroom bodies show overextension of axons. Earlier born clones also show cell proliferation defects. Single cell Mkk4[e01485] clones in mushroom bodies show a low frequency of axon breaks. (Rallis et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Mkk4^e01485 has neuroanatomy defective \| somatic clone phenotype, enhanceable by hep^r75 (Rallis et al., 2010)
Suppressed by
Statement Reference Mkk4^e01485 has neuroanatomy defective \| somatic clone phenotype, suppressible by hep^Scer\UAS.cBa/Scer\GAL4^ey-OK107 (Rallis et al., 2010)
Enhancer of
Statement Reference Mkk4^e01485 is an enhancer of neuroanatomy defective \| somatic clone phenotype of hep^r75 (Rallis et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Mkk4^e01485 has axon \| somatic clone phenotype, enhanceable by hep^r75 (Rallis et al., 2010) Mkk4^e01485 has Kenyon cell \| somatic clone phenotype, enhanceable by hep^r75 (Rallis et al., 2010)
Suppressed by
Statement Reference Mkk4^e01485 has axon \| somatic clone phenotype, suppressible by hep^Scer\UAS.cBa/Scer\GAL4^ey-OK107 (Rallis et al., 2010) Mkk4^e01485 has Kenyon cell \| somatic clone phenotype, suppressible by hep^Scer\UAS.cBa/Scer\GAL4^ey-OK107 (Rallis et al., 2010)
Enhancer of
Statement Reference Mkk4^e01485 is an enhancer of axon \| somatic clone phenotype of hep^r75 (Rallis et al., 2010) Mkk4^e01485 is an enhancer of Kenyon cell \| somatic clone phenotype of hep^r75 (Rallis et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference The axon overextension phenotype of Mkk4[e01485] neuroblast clones in mushroom bodies is suppressed by expression of hep[Scer\UAS.cBa] using Scer\GAL4[ey-OK107]. Single cell Mkk4[e01485], hep[r75] double mutant clones in mushroom bodies show a higher frequency of axon breaks than in clones of either single mutant. (Rallis et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Df(3R)p13/Mkk4^e01485 is rescued by Scer\GAL4^tub.PU/Mkk4^{Scer\UAS.T:Avic\GFP-YFP} (Rallis et al., 2010) Mkk4^e01485 is rescued by Scer\GAL4^ey-OK107/Mkk4^{Scer\UAS.T:Avic\GFP-YFP} (Rallis et al., 2010)
Comments	Expression of Mkk4[Scer\UAS.T:Avic\GFP-YFP] using Scer\GAL4[tub] fully rescues the lethality associated with Mkk4[e01485]/Df(3R)p13. Expression of Mkk4[Scer\UAS.T:Avic\GFP-YFP] with Scer\GAL4[ey-OK107] rescues the axonal phenotypes seen in Mkk4[e01485] mushroom body clones. (Rallis et al., 2010)
Stocks ( 2 )
Bloomington	17956 w¹¹¹⁸; PBac{RB}Mkk4^e01485/TM6B, Tb¹
Harvard	- PBac{RB}Mkk4^e01485
Notes on Origin
Discoverer

Comments
	FlyBase Curator comment: Authors refer to 'Mkk4[e01458]' but this must be a typo for Mkk4[e01485]. (Rallis et al., 2010)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	MAPKK4^e01485 (Guichard et al., 2006) Mkk4^e01485
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Rallis et al., 2010, Dev. Biol. 339(1): 65--77 Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. [FBrf0209975] Guichard et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(9): 3244--3249 Anthrax lethal factor and edema factor act on conserved targets in Drosophila. [FBrf0191441]

Allele Dmel\Mkk4e01485

Allele Dmel\Mkk4^e01485