A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\BsgScer\UAS.cBa

General Information
SymbolDmel\BsgScer\UAS.cBaSpeciesD. melanogaster
NameFlyBase IDFBal0243209
Feature typealleleAssociated geneDmel\Bsg
Allele class
Mutagenin vitro construct - regulatory fusion
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Besse et al., 2007)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Scer\UAS regulatory sequences drive expression of full-length Bsg coding sequences.
(Besse et al., 2007)
Carried in construct
P{UAS-Bsg.B}
(Besse et al., 2007)
Cytology
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Statement
Reference
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Statement
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Statement
Reference
hide Complementation & Rescue Data
Rescues
Scer\GAL4elav-C155/BsgScer\UAS.cBa rescues BsgNP3198/Df(2L)Exel7034
(Besse et al., 2007)
Scer\GAL4tub.PU/BsgScer\UAS.cBa rescues BsgNP3198/Df(2L)Exel7034
(Besse et al., 2007)
Scer\GAL4tub.PU/BsgScer\UAS.cBa rescues Df(2L)Exel7034/Bsgk13638
(Besse et al., 2007)
Scer\GAL4tub.PU/BsgScer\UAS.cBa rescues Df(2L)Exel7034/Bsgk14308
(Besse et al., 2007)
Fails to rescue
Scer\GAL4how-24B, Scer\GAL4how-24B, BsgScer\UAS.cBa fails to rescue BsgNP3198/Df(2L)Exel7034
(Besse et al., 2007)
Scer\GAL4Mhc.PW/BsgScer\UAS.cBa fails to rescue BsgNP3198/Df(2L)Exel7034
(Besse et al., 2007)
Comments
Bsg[k13638]/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of Bsg[Scer\UAS.cBa] under the control of Scer\GAL4[tub]. Bsg[k14308]/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of Bsg[Scer\UAS.cBa] under the control of Scer\GAL4[tub]. Bsg[NP3198]/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of Bsg[Scer\UAS.cBa] under the control of Scer\GAL4[tub]. Presynaptic expression of Bsg[Scer\UAS.cBa] (under the control of Scer\GAL4[elav-C155] in a Bsg[NP6293]/Df(2L)Exel7034 mutant background rescues both the asynchronous evoked release and the high frequency of spontaneous release. Presynaptic expression decreases the amplitude of eEJCs and the frequency of single vesicle release below control levels, indicating a dose-dependent role. Expression post-synaptically, under the control of Scer\GAL4[Mhc.PW] does not rescue. Expression of wild-type Bsg[Scer\UAS.cBa] solely in muscles (using Scer\GAL4[Mhc.PW] or Scer\GAL4[how-24B]) or in neurons (using Scer\GAL4[elav-C155]) partially, but significantly, rescued both the increase in bouton size and the reduction of bouton number observed in Bsg[NP6293]/Df(2L)Exel7034 mutant larvae. Near-complete rescue of bouton size and junction growth is obtained upon expression of Bsg[Scer\UAS.cBa] both pre- and postsynaptically (using Scer\GAL4[Mhc.PW] or Scer\GAL4[how-24B] post-synaptically and Scer\GAL4[elav-C155] pre-synaptically).
(Besse et al., 2007)
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Reported As
Symbol Synonym
BsgScer\UAS.cBa
 
Name Synonym
Secondary FlyBase IDs
hide References ( 1 )
Research paper
Besse et al., 2007, J. Cell Biol. 177(5): 843--855
The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. [FBrf0202422]