FlyBase Allele Report: Hsap\MIR200C[UAS.cHa]

General Information

Symbol

Hsap\MIR200C^UAS.cHa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Hyun

FlyBase ID

FBal0243244

Feature type

allele

Associated gene

Hsap\MIR200C

Associated Insertion(s)

Carried in Construct

P{UAS-mir-200-c}

Key Links

Transgenic product class

wild_type

(Hyun et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Hyun et al., 2009)

Mutagen

in vitro construct

(Hyun et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-mir-200-c}

Cytology

Description

UAS regulatory sequences drive expression of the Hsap\MIR200C and Hsap\MIR141 miRNAs.

(Hyun et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MIR200C

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^repo

(Morante et al., 2013)

increased cell size | third instar larval stage, with Scer\GAL4^repo

(Morante et al., 2013)

Phenotype Manifest In

larval brain | third instar larval stage, with Scer\GAL4^repo

(Morante et al., 2013)

larval glial cell | third instar larval stage, with Scer\GAL4^repo

(Morante et al., 2013)

Detailed Description

Statement

Reference

Overexpression of Hsap\MIR200C^Scer\UAS.cHa in all glia using Scer\GAL4^repo cell-autonomously increases surface glial size in L3 larval brains.

(Morante et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\MIR200C^UAS.cHa, Scer\GAL4^Cg.PA, Hsap\MIR141^UAS.cHa is a suppressor of decreased body size phenotype of mir-8^Δ2

(Hyun et al., 2009)

Hsap\MIR200C^UAS.cHa, Scer\GAL4^ppl.PP, Hsap\MIR141^UAS.cHa is a suppressor of decreased body size phenotype of mir-8^Δ2

(Hyun et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of P{UAS-mir-200-c} (which encodes Hsap\MIR200C^Scer\UAS.cHa and Hsap\MIR141^Scer\UAS.cHa) under the control of either Scer\GAL4^Cg.PA or Scer\GAL4^ppl.PP rescues the reduced weight of mir-8^Δ2 adults to near that of wild type.

(Hyun et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\MIR200C^Scer\UAS.cHa

Hsap\MIR200C^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hyun

Secondary FlyBase IDs

References (2)

Report Sections

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