|Feature type||allele||Associated gene||Dmel\cno|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: K211@.
|Phenotype Manifest In|
Zygotic cno[R2] mutant embryos die; 88% have defects in head involution but close dorsally, whereas 11% have defects in head involution and dorsal closure. Loss of maternal cno[R2] is not fully rescued by zygotic wild-type cno; ~30% of paternally rescued mutants die with defects in head involution. cno[R2] maternal+zygotic mutants are much more severe than zygotic mutants, which is consistent with strong maternal contribution. Most maternal/zygotic cno[R2] embryos (83%) entirely lack ventral cuticle, but retain dorsal cuticle. Initial adherens junctions in cno[R2] maternal and zygotic mutants is indistinguishable from wild-type. Maturation of spot adherens junctions to belt adherens junctions also proceeds normally. cno[R2] mutants do not completely internalize mesoderm during gastrulation (as in wild-type); many cells remain on the embryo surface and begin to divide in this aberrant location. While cno[R2] mutant mesodermal cells initiate constriction fairly synchronously, they arrest partway through apical constriction. The phenotype is variable. In less severe mutants, constriction goes at the same rate as in wild-type but halts prematurely. In more severe embryos, constriction is slower than in wild-type, and more cells lag behind. cno[R2] cells apically constrict without fully effective linkage between adherens junctions and the actomyosin network, the contractile network detaches from adherens junctions before full cell constriction, and mesodermal cells are not efficiently internalized. cno[R2] mutants successfully internalize the gut, although the midgut epithelium may be less organised. Ectodermal cells in cno[R2] mutants planar polarize myosin and adherens junction proteins in an even more pronounced manner than wild-type. They retain accentuated planar polarity through the end of germband extension.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|