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General Information
Symbol
Dmel\Laspy45
Species
D. melanogaster
Name
FlyBase ID
FBal0243456
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Reported as a deletion of 2859 bp from the site of the P{wHy}LaspDG14505 insertion at nt 16675541 (release 5.7).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{wHy}LaspDG14505 resulting in a 2859 bp deletion (with respect to the original insertion point of P{wHy}LaspDG14505).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

40-50% of Laspy45 mutant eggs fail to develop due to lack of fertilisation. The remaining embryos hatch and develop normally. Homozygous mutant Laspy45 females all contain normally developed ovaries.

The progeny of Laspy45/+ develop no germline (grandchildless phenotype) at very low penetrance.

An average of 26 pole cells are observed in Laspy45 mutant stage 11 embryos, slightly reduced compared to wildtype numbers (average of 33 pole cells).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Laspy45 has grandchildless | dominant phenotype, enhanceable by osk[+]/osk1

Suppressed by
NOT suppressed by
Enhancer of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Suppressed by
NOT suppressed by
Enhancer of
Statement
Reference

Laspy45 is an enhancer of ovary phenotype of osk1

Other
Additional Comments
Genetic Interactions
Statement
Reference

osk1/+ females lacking both copies of Laspy45 show a penetrant grandchildless phenotype, with 20% of offspring displaying a complete absence of ovaries, and another 25% show only a single ovary.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of LaspL.Scer\UAS.P\T restores the hatching defect in Laspy45 mutants.

Stage 11 embryos from osk1/+ females lacking both copies of Laspy45 develop an average of 12 pole cells, much reduced compared to osk1/+ animals.

Laspy45, osk1/Laspy41 females have a grandchildless phenotype, which is rescued by expression of LaspL.Scer\UAS.P\T under the control of Scer\GAL4otd. The number of pole cells is partially rescued, increasing to 25 pole cells in stage 11 embryos.

The grandchildless phenotype of Laspy45, osk1/Laspy41 females is not rescued by expression of LaspWA.Scer\UAS.P\T or LaspS.Scer\UAS.P\T under the control of Scer\GAL4otd. There is no increase in the number of pole cells observed in these embryos.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Laspy45
Name Synonyms
Secondary FlyBase IDs
    References (1)