FB2025_01 , released February 20, 2025
Allele: Dmel\cpxUAS.cXa
Open Close
General Information
Symbol
Dmel\cpxUAS.cXa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Xue
FlyBase ID
FBal0243462
Feature type
allele
Associated gene
Dmel\cpx
Associated Insertion(s)
Carried in Construct
P{UAS-cpx.X}
Key Links
Transgenic product class
cDNA
(Xue et al., 2009)
wild_type
(Xue et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Xue et al., 2009)
wild_type
(Xue et al., 2009)
Mutagen
in vitro construct
(Xue et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-cpx.X}
Cytology
Description

UASt drives expression of wild type cpx derived from the GH27718 cDNA.

(Xue et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cpx
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of cpxScer\UAS.cXa using Scer\GAL4elav-C155 or Scer\GAL4n-syb.PS decreases miniature excitatory junction potential (mEJP) frequency without affecting mEJP amplitude, but has no effect on evoked EJPs at the larval neuromuscular junction.

      (Xue et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/cpxUAS.cXa rescues cpxSH1

      (Xue et al., 2009)
      Comments

      Expression of cpxScer\UAS.cXa using Scer\GAL4elav-C155 rescues the lethality and sterility of cpxSH1 mutants.

      Expression of cpxScer\UAS.cXa rescues the decreased evoked excitatory junction potentials (EJPs) and the increased spontaneous EJPs in cpxSH1 mutants.

      (Xue et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cpxScer\UAS.cXa
      cpxUAS.cXa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Xue
      Secondary FlyBase IDs
        References (1)