Allele Mmus\Cplx3^Scer\UAS.cXa

General Information
Symbol	Mmus\Cplx3^Scer\UAS.cXa	Species	M. musculus
Name	Saccharomyces cerevisiae UAS construct a of Xue	FlyBase ID	FBal0243464
Feature type	allele	Associated gene	Mmus\Cplx3

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Xue et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS drives expression of a wild type Mmus\Cplx3 cDNA. (Xue et al., 2009)
Carried in construct	P{UAS-Mmus\Cplx3.X} (Xue et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective \| third instar larval stage, with Scer\GAL4^elav-C155 (Xue et al., 2009) neurophysiology defective \| third instar larval stage, with Scer\GAL4^n-syb.PS (Xue et al., 2009)
Phenotype Manifest In
	embryonic/larval neuromuscular junction \| third instar larval stage, with Scer\GAL4^elav-C155 (Xue et al., 2009) embryonic/larval neuromuscular junction \| third instar larval stage, with Scer\GAL4^n-syb.PS (Xue et al., 2009)
Detailed Description
	Statement Reference Overexpression of Mmus\Cplx3[Scer\UAS.cXa] using Scer\GAL4[elav-C155] or Scer\GAL4[n-syb.PS] increases miniature excitatory junction potential (mEJP) frequency, increases evoked EJP amplitude, and increases the quantal content of evoked release at the larval neuromuscular junction. (Xue et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^elav-C155/Mmus\Cplx3^Scer\UAS.cXa is a suppressor of neurophysiology defective \| third instar larval stage phenotype of cpx^SH1 (Xue et al., 2009) Scer\GAL4^elav-C155/Mmus\Cplx3^Scer\UAS.cXa is a suppressor of partially lethal - majority die phenotype of cpx^SH1 (Xue et al., 2009) Scer\GAL4^elav-C155/Mmus\Cplx3^Scer\UAS.cXa is a suppressor of sterile phenotype of cpx^SH1 (Xue et al., 2009)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of Mmus\Cplx3[Scer\UAS.cXa] using Scer\GAL4[elav-C155] rescues the lethality and sterility of cpx[SH1] mutants. Expression of Mmus\Cplx3[Scer\UAS.cXa] using Scer\GAL4[elav-C155] rescues the decreased evoked excitatory junction potentials (EJPs) and partially suppresses the increased spontaneous EJPs in cpx[SH1] mutants. (Xue et al., 2009)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	39744 y¹ w^*; P{UAS-Mmus\Cplx3.X}2
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Mmus\Cplx3^Scer\UAS.cXa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Xue
Secondary FlyBase IDs

References ( 1 )
Research paper	Xue et al., 2009, Neuron 64(3): 367--380 Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. [FBrf0209287]

Allele Mmus\Cplx3Scer\UAS.cXa

Allele Mmus\Cplx3^Scer\UAS.cXa