FlyBase Allele Report: Mmus\Cplx3[UAS.cXa]

General Information

Symbol

Mmus\Cplx3^UAS.cXa

Species

M. musculus

Name

Saccharomyces cerevisiae UAS construct a of Xue

FlyBase ID

FBal0243464

Feature type

allele

Associated gene

Mmus\Cplx3

Associated Insertion(s)

Carried in Construct

P{UAS-Mmus\Cplx3.X}

Transgenic product class

cDNA

(Xue et al., 2009)

wild_type

(Xue et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Xue et al., 2009)

wild_type

(Xue et al., 2009)

Mutagen

in vitro construct

(Xue et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Mmus\Cplx3.X}

Cytology

Description

UASt drives expression of a wild type Mmus\Cplx3 cDNA.

(Xue et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mmus\Cplx3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^elav-C155

(Xue et al., 2009)

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^nSyb.PS

(Xue et al., 2009)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

(Xue et al., 2009)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

(Xue et al., 2009)

Detailed Description

Statement

Reference

Overexpression of Mmus\Cplx3^Scer\UAS.cXa using Scer\GAL4^elav-C155 or Scer\GAL4^n-syb.PS increases miniature excitatory junction potential (mEJP) frequency, increases evoked EJP amplitude, and increases the quantal content of evoked release at the larval neuromuscular junction.

(Xue et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Mmus\Cplx3^UAS.cXa is a suppressor of partially lethal - majority die phenotype of cpx^SH1

(Xue et al., 2009)

Scer\GAL4^elav-C155/Mmus\Cplx3^UAS.cXa is a suppressor of sterile phenotype of cpx^SH1

(Xue et al., 2009)

Scer\GAL4^elav-C155/Mmus\Cplx3^UAS.cXa is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of cpx^SH1

(Xue et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Cplx3^Scer\UAS.cXa using Scer\GAL4^elav-C155 rescues the lethality and sterility of cpx^SH1 mutants.

Expression of Mmus\Cplx3^Scer\UAS.cXa using Scer\GAL4^elav-C155 rescues the decreased evoked excitatory junction potentials (EJPs) and partially suppresses the increased spontaneous EJPs in cpx^SH1 mutants.

(Xue et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39744

y¹ w^*; P{UAS-Mmus\Cplx3.X}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mmus\Cplx3^Scer\UAS.cXa

Mmus\Cplx3^UAS.cXa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Xue

Secondary FlyBase IDs

References (1)

Report Sections

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