Allele Dmel\mam^k1514

General Information
Symbol	Dmel\mam^k1514	Species	D. melanogaster
Name		FlyBase ID	FBal0243521
Feature type	allele	Associated gene	Dmel\mam

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Endo et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A single nucleotide substitution in the coding sequence of mam results in a truncated protein of 83 amino acids from the N-terminus. (Endo et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Endo et al., 2007)
Phenotype Manifest In
	adult olfactory receptor neuron Or49a/85f (Endo et al., 2007) antennal lobe glomerulus DA1 (Endo et al., 2007) antennal lobe glomerulus DA3 (Endo et al., 2007) antennal lobe glomerulus DA4l (Endo et al., 2007) antennal lobe glomerulus DC1 (Endo et al., 2007) antennal lobe glomerulus DL1 (Endo et al., 2007) antennal lobe glomerulus DL4 (Endo et al., 2007) antennal lobe glomerulus DM1 (Endo et al., 2007) antennal lobe glomerulus DM2 (Endo et al., 2007) antennal lobe glomerulus DM3 (Endo et al., 2007) antennal lobe glomerulus DM4 (Endo et al., 2007) antennal lobe glomerulus V (Endo et al., 2007) antennal lobe glomerulus VA4 (Endo et al., 2007) antennal lobe glomerulus VC1 (Endo et al., 2007) antennal lobe glomerulus VC2 (Endo et al., 2007) antennal lobe glomerulus VC3 (Endo et al., 2007) antennal lobe glomerulus VC3l (Endo et al., 2007) antennal lobe glomerulus VC4 (Endo et al., 2007) antennal lobe glomerulus VL1 (Endo et al., 2007) antennal lobe glomerulus VM1 (Endo et al., 2007) antennal lobe glomerulus VM4 (Endo et al., 2007) olfactory receptor neuron (Endo et al., 2007)
Detailed Description
	Statement Reference In mam[k1514] mutants, the axonal projection to glomerulus DL4 is abolished, while the projection to DM6 remains. mam[k1514] mutants autonomously switch both the axonal pathway and the target glomerulus of the olfactory neurons projecting to DL4 to those of the olfactory neurons projecting to DM6. In mam[k1514] mutants, the axonal projections to glomeruli VL1, VM4, VC3l, VM1, VC3m, VC5, VC1, VA4, VC2, VC4, DL1, DM1, V, DM4, DM2, DM3, DA4l, DC1, DA3, and DA1 are abolished. mam[k1514] olfactory organ cell clones induced at 30 hours before puparium formation and analyzed at 20-24 hours after puparium formation contain eight cells that stain with sens indicating they are pNb progeny, suggesting that all the progenies of PIIa and pIIB transform to pNb-like cells. (Endo et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Kyoto	109584 w^*; P{FRT(w^hs)}G13 mam^k1514 P{UAS-mCD8::GFP.L}LL5 / SM1
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mam^k1514 (Endo et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Endo et al., 2007, Nat. Neurosci. 10(2): 153--160 Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages. [FBrf0192533]

Allele Dmel\mamk1514

Allele Dmel\mam^k1514