Allele Dmel\mir-124^Scer\UAS.cXa

General Information
Symbol	Dmel\mir-124^Scer\UAS.cXa	Species	D. melanogaster
Name		FlyBase ID	FBal0243579
Feature type	allele	Associated gene	Dmel\mir-124

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - genomic fragment
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - genomic fragment (Xu et al., 2008) in vitro construct - regulatory fusion (Xu et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of a 92bp genomic DNA fragment containing the 77 nucleotide pre- mir-124 sequence. (Xu et al., 2008)
Carried in construct	P{UAS-pre-mir-124a} (Xu et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4²²¹ (Xu et al., 2008) neuroanatomy defective, with Scer\GAL4⁴⁷⁷ (Xu et al., 2008)
Phenotype Manifest In
	abdominal 1 dorsal multidendritic neuron ddaC, with Scer\GAL4⁴⁷⁷ (Xu et al., 2008) abdominal 1 dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹ (Xu et al., 2008) abdominal 1 dorsal multidendritic neuron ddaF, with Scer\GAL4²²¹ (Xu et al., 2008) dendrite, with Scer\GAL4²²¹ (Xu et al., 2008) dendrite, with Scer\GAL4⁴⁷⁷ (Xu et al., 2008) dendritic arborizing neuron, with Scer\GAL4²²¹ (Xu et al., 2008)
Detailed Description
	Statement Reference Ectopic expression of mir-124[Scer\UAS.cXa] in ddaE, ddaF and DA neurons in the dorsal cluster under the control of Scer\GAL4[221] results in significantly fewer dendritic ends than in wild-type neurons. Ectopic expression of mir-124[Scer\UAS.cXa] in ddaC neurons (under the control of Scer\GAL4[477]) decreases the number of dendritic ends and the size of the dendritic field compared with wild-type neurons. (Xu et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has neuroanatomy defective phenotype, suppressible \| partially by Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has neuroanatomy defective phenotype, suppressible \| partially by Fmr1^4.L/Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has neuroanatomy defective phenotype, suppressible by Dcr-1^Q1147X (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has neuroanatomy defective phenotype, suppressible by Dcr-1^Q1948X (Xu et al., 2008)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has abdominal 1 dorsal multidendritic neuron ddaC phenotype, suppressible \| partially by Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has abdominal 1 dorsal multidendritic neuron ddaC phenotype, suppressible \| partially by Fmr1^4.L/Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has abdominal 1 dorsal multidendritic neuron ddaC phenotype, suppressible by Dcr-1^Q1147X (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has abdominal 1 dorsal multidendritic neuron ddaC phenotype, suppressible by Dcr-1^Q1948X (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has dendrite phenotype, suppressible \| partially by Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has dendrite phenotype, suppressible \| partially by Fmr1^4.L/Fmr1³ (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has dendrite phenotype, suppressible by Dcr-1^Q1147X (Xu et al., 2008) Scer\GAL4⁴⁷⁷, mir-124^Scer\UAS.cXa has dendrite phenotype, suppressible by Dcr-1^Q1948X (Xu et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference Ectopic expression of mir-124[Scer\UAS.cXa] in ddaC neurons (under the control of Scer\GAL4[477]) in a homozygous Fmr1[3] or Fmr1[3]/Fmr1[4.L] background results in a significantly attenuated phenotype, where the number of dendritic ends is partially rescued (although not to the wild-type level). Interestingly, the dendritic fields of ddaC neurons are similar in size to those of wild-type neurons. Ectopic expression of mir-124[Scer\UAS.cXa] in homozygous Dcr-1[d102] or Dcr-1[Q1147X] ddaC neuron clones (under the control of Scer\GAL4[477]) does not affect the number of dendritic ends, indicating Dcr-1 suppression of mir-124 function. (Xu et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mir-124^Scer\UAS.cXa
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Xu et al., 2008, J. Neurosci. 28(46): 11883--11889 The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila. [FBrf0206327]

Allele Dmel\mir-124Scer\UAS.cXa

Allele Dmel\mir-124^Scer\UAS.cXa