Open Close
General Information
Symbol
Dmel\robo2KO.robo1
Species
D. melanogaster
Name
FlyBase ID
FBal0243808
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
The exons (and intervening small introns) that encode the mature robo2 protein have been replaced with a single exon encoding full length robo1 tagged with Tag:HA. The robo2KO.robo1 allele represents the loss of the robo2 open reading frame at the endogenous robo2 locus, while the robo1robo2.HR.Tag:HA allele represents the mature robo1 protein tagged with Tag:HA that is expressed under the control of the robo2 regulatory sequences in place of robo2.
Insertion components
TI{robo1-HA}robo2KO.robo1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The defects in the lateral Fas2-expressing longitudinal axons that are seen in lea mutant embryos are not rescued in leaKO.robo robolea.HR.T:Ivir\HA1 double homozygous embryos (33.0% of hemisegments have fused or broken lateral Fas2-positive fascicles). Fas2-positive longitudinal axons cross the midline in only 2.0% of segments in the leaKO.robo robolea.HR.T:Ivir\HA1 double homozygous embryos (compared to in 23.7% of segments in lea null mutant embryos).
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
leaKO.robo
robo2KO.robo1
robo2KO.robo
Name Synonyms
Secondary FlyBase IDs
    References (1)