Allele Dmel\Tor^NIG.5092R

General Information
Symbol	Dmel\Tor^NIG.5092R	Species	D. melanogaster
Name		FlyBase ID	FBal0243869
Feature type	allele	Associated gene	Dmel\Tor

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Juhász et al., 2008) in vitro construct - RNAi (Juhász et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..226 :227..447 :448..500
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Tor double-stranded RNA. (Juhász et al., 2008)
Carried in construct	P{NIG.5092R} (Juhász et al., 2008, Resnik-Docampo and de Celis, 2011, Chakrabarti et al., 2012)
Associated Sequence Features	dsRNA-5092R
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell size, with Scer\GAL4^nub-AC-62 (Resnik-Docampo and de Celis, 2011) decreased cell size \| somatic clone, with Scer\GAL4^Act5C.PP (Juhász et al., 2008) size defective, with Scer\GAL4^nub-AC-62 (Resnik-Docampo and de Celis, 2011)
Phenotype Manifest In
	embryonic/larval fat body, with Scer\GAL4^ppl.PP (Resnik-Docampo and de Celis, 2011) fat body \| somatic clone, with Scer\GAL4^Act5C.PP (Juhász et al., 2008) wing, with Scer\GAL4^nub-AC-62 (Resnik-Docampo and de Celis, 2011)
Detailed Description
	Statement Reference Expression of Tor[NIG.5092R] using Scer\GAL4[nub-AC-62] results in abnormally small wings in which cell size is decreased. Expression of Tor[NIG.5092R] with Scer\GAL4[ppl.PP] causes the fusion of lipid vesicles in the fat body. (Resnik-Docampo and de Celis, 2011) Expression of Tor[NIG.5092R] under the control of Scer\GAL4[Act5C.PP] results in a significant reduction in fat-body cell size. (Juhász et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^nub-AC-62, Tor^NIG.5092R has decreased cell number phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011) Scer\GAL4^nub-AC-62, Tor^NIG.5092R has decreased cell size phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011) Scer\GAL4^nub-AC-62, Tor^NIG.5092R has size defective phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011)
Enhancer of
Statement Reference Scer\GAL4^nub-AC-62/Tor^NIG.5092R is an enhancer of decreased cell number phenotype of Scer\GAL4^nub-AC-62, hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011) Scer\GAL4^nub-AC-62/Tor^NIG.5092R is an enhancer of decreased cell size phenotype of Scer\GAL4^nub-AC-62, hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011) Scer\GAL4^nub-AC-62/Tor^NIG.5092R is an enhancer of size defective phenotype of Scer\GAL4^nub-AC-62, hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^nub-AC-62, Tor^NIG.5092R has wing phenotype, enhanceable by Scer\GAL4^nub-AC-62/hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011)
Enhancer of
Statement Reference Scer\GAL4^nub-AC-62/Tor^NIG.5092R is an enhancer of wing phenotype of Scer\GAL4^nub-AC-62, hppy^Scer\UAS.cMa (Resnik-Docampo and de Celis, 2011)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of hppy[Scer\UAS.cMa] and Tor[NIG.5092R] using Scer\GAL4[nub-AC-62] results in a strong synergistic phenotype of reduced wing size and reduced cell size and number. (Resnik-Docampo and de Celis, 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Tor^NIG.5092R
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70 Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Juhász et al., 2008, J. Cell Biol. 181(4): 655--666 The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. [FBrf0204844]

Allele Dmel\TorNIG.5092R

Allele Dmel\Tor^NIG.5092R