FlyBase Allele Report: Dmel\N[UAS.Tag:V5,Tag:polyHis]

General Information

Symbol

Dmel\N^{UAS.Tag:V5,Tag:polyHis}

Species

D. melanogaster

Name

FlyBase ID

FBal0243919

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.V5}

Also Known As

UAS-Notch-V5, UAS-N-V5

Key Links

Transgenic product class

wild_type

(Kanwar and Fortini, 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kanwar and Fortini, 2008)

Mutagen

in vitro construct

(Kanwar and Fortini, 2008)

Progenitor genotype

Carried in construct

P{UAS-N.V5}

Cytology

Description

UASt regulatory sequences drive expression of full-length N which is tagged with Tag:V5 and Tag:polyHis tags after the sequence QQLGG in the N intracellular domain.

(Kanwar and Fortini, 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of brain cancer

CEA

(Ojha et al., 2022)

model of cancer

CEA

(Khaket et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of brain cancer

is ameliorated by ND-49^HM05059

(Ojha et al., 2022)

is ameliorated by Scer\NDI1^UAS.cBa

(Ojha et al., 2022)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-GA^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-PR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

model of cancer

is ameliorated by pix^{UAS.ORF.Tag:HA}

(Khaket et al., 2024)

is ameliorated by CG11414^HMJ23120

(Khaket et al., 2024)

is ameliorated by Cnot4^JF03203

(Khaket et al., 2024)

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Khaket et al., 2024)

is ameliorated by TER94^JF03402

(Khaket et al., 2024)

is ameliorated by pelo^KK101657

(Khaket et al., 2024)

is ameliorated by pelo^{UAS.ORF.GW.Tag:HA}

(Khaket et al., 2024)

is ameliorated by pix^JF01190

(Khaket et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR9D11

(Lee et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^insc-Mz1407

(Lee et al., 2013, Song and Lu, 2012)

abnormal neuroanatomy, with Scer\GAL4^pnt-14-94

(Lee et al., 2013)

abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^pnt-14-94

(Liu et al., 2017)

decreased cell number | somatic clone, with Scer\GAL4^NP5130

(Xu et al., 2018)

hyperplasia, with Scer\GAL4^insc-Mz1407

(Song and Lu, 2012)

increased cell number | larval stage | somatic clone, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

increased cell number | third instar larval stage, with Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

increased cell number | third instar larval stage, with Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Phenotype Manifest In

larval brain, with Scer\GAL4^insc-Mz1407

(Song and Lu, 2012)

larval brain | third instar larval stage, with Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

larval brain | third instar larval stage, with Scer\GAL4^pnt-14-94

(Liu et al., 2017)

larval neuroblast | increased number, with Scer\GAL4^insc-Mz1407

(Song and Lu, 2012)

Malpighian tubule | somatic clone, with Scer\GAL4^NP5130

(Xu et al., 2018)

neuroblast | increased number, with Scer\GAL4^GMR9D11

(Lee et al., 2013)

neuroblast | third instar larval stage, with Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

type II neuroblast | increased number, with Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

type II neuroblast | increased number, with Scer\GAL4^pnt-14-94

(Lee et al., 2013)

type II neuroblast | larval stage | somatic clone | increased number, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

type II neuroblast | third instar larval stage, with Scer\GAL4^pnt-14-94

(Liu et al., 2017)

Detailed Description

Statement

Reference

The clonal expression of N^{UAS.Tag:V5,Tag:polyHis} under the control of Scer\GAL4^esg-NP5130 leads to a strong reduction in the number of progenitor cells in renal tubules, as compared to controls.

(Xu et al., 2018)

The expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407 or Scer\GAL4^pnt-14-94 leads to severe increases in the numbers of total or type II neuroblasts, respectively, per third instar larval brain lobe, as compared to controls.

(Liu et al., 2017)

Larval brains expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407 exhibit ectopic formation and increased numbers of type II neuroblasts, as compared to controls.

(Wu et al., 2017)

Expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of either Scer\GAL4^insc-Mz1407 or Scer\GAL4^pnt-14-94 results in an increase in the number of type II neuroblasts in the central brain compared to wild type.

Expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^GMR9D11 results in an increase in the number of brain neuroblasts compared to wild type.

(Lee et al., 2013)

Larval brains overexpressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407 contain supernumerary neuroblasts.

(Song and Lu, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | larval stage phenotype, enhanceable by mir-ban^D.UAS.EGFP, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | larval stage phenotype, enhanceable by mir-ban^D.UAS.EGFP, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^pnt-14-94 has abnormal neuroanatomy phenotype, enhanceable by rictor^UAS.cHa, Scer\GAL4^pnt-14-94

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^pnt-14-94 has abnormal neuroanatomy phenotype, enhanceable by Pink1^UAS.cYa, Scer\GAL4^pnt-14-94

(Lee et al., 2013)

NOT Enhanced by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-enhanceable by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-enhanceable by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by pros[+]/pros¹⁷

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-enhanceable by pros[+]/pros¹⁷

(Wu et al., 2017)

Suppressed by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^NP5130 has decreased cell number | somatic clone phenotype, suppressible by ct^HMS00924, Scer\GAL4^NP5130

(Xu et al., 2018)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | third instar larval stage phenotype, suppressible by Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | third instar larval stage phenotype, suppressible by E(spl)mγ-HLH^UAS.cLb/Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by E(spl)mγ-HLH^UAS.cLb/Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | larval stage phenotype, suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | larval stage phenotype, suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by rictor^JF01086, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by Akt^HMS00007, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by ND-75^NIG.2286R, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by srl^HMS00857, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by Drp1^{K38A.UAS.Tag:HA}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by Su(H)^HM05110/Pink1^RNAi.UAS.cYa, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

NOT suppressed by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-suppressible by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-suppressible by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by numb^HMS01459/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | larval stage phenotype, non-suppressible by numb^HMS01459/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}/numb[+]/numb¹⁵, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | larval stage phenotype, non-suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}/numb[+]/numb¹⁵, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | somatic clone | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | somatic clone | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | somatic clone | larval stage phenotype, non-suppressible by numb[+]/numb¹⁵

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | somatic clone | larval stage phenotype, non-suppressible by numb[+]/numb¹⁵

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | somatic clone | larval stage phenotype, non-suppressible by Myc^UAS.cZa/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-suppressible by pros[+]/pros¹⁷

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | somatic clone | larval stage phenotype, non-suppressible by Myc^UAS.cZa/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | somatic clone | larval stage phenotype, non-suppressible by HUWE1^HMS01605/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has increased cell number | somatic clone | larval stage phenotype, non-suppressible by HUWE1^HMS01605/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-suppressible by pros[+]/pros¹⁷

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has abnormal neuroanatomy | larval stage phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has increased cell number | larval stage phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, non-suppressible by UQCR-14L^GD9481, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Suppressor of

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}/Scer\GAL4^Mhc.PW is a suppressor of visible | progressive phenotype of Pink1^B9

(Lee et al., 2013)

Other

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^NP5130, ct^HMS00924 has increased cell number phenotype

(Xu et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | larval stage | increased number phenotype, enhanceable by mir-ban^D.UAS.EGFP, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^pnt-14-94 has type II neuroblast | increased number phenotype, enhanceable by rictor^UAS.cHa, Scer\GAL4^pnt-14-94

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^pnt-14-94 has type II neuroblast | increased number phenotype, enhanceable by Pink1^UAS.cYa, Scer\GAL4^pnt-14-94

(Lee et al., 2013)

NOT Enhanced by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | larval stage | increased number phenotype, non-enhanceable by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | larval stage | increased number phenotype, non-enhanceable by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | larval stage | increased number phenotype, non-enhanceable by pros[+]/pros¹⁷

(Wu et al., 2017)

Suppressed by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^NP5130 has Malpighian tubule | somatic clone phenotype, suppressible by ct^HMS00924, Scer\GAL4^NP5130

(Xu et al., 2018)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has neuroblast | third instar larval stage phenotype, suppressible by Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has neuroblast | third instar larval stage phenotype, suppressible by E(spl)mγ-HLH^UAS.cLb/Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has larval brain | third instar larval stage phenotype, suppressible by Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has larval brain | third instar larval stage phenotype, suppressible by E(spl)mγ-HLH^UAS.cLb/Cdk9^D199N.UAS.SR, Scer\GAL4^insc-Mz1407

(Liu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by rictor^JF01086, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by Akt^HMS00007, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by ND-75^NIG.2286R, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by srl^HMS00857, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by Drp1^{K38A.UAS.Tag:HA}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by Su(H)^HM05110/Pink1^RNAi.UAS.cYa, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, suppressible by Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

NOT suppressed by

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by numb^HMS01459/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by mir-ban^{sponge.UAS.DsRed(Unk)}/numb[+]/numb¹⁵, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by numb[+]/numb¹⁵

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by Myc^UAS.cZa/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number | larval stage phenotype, non-suppressible by HUWE1^HMS01605/mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | increased number | larval stage phenotype, non-suppressible by brat[+]/brat^k06028

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | increased number | larval stage phenotype, non-suppressible by pros[+]/pros¹⁷

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407, mir-ban^{sponge.UAS.DsRed(Unk)} has type II neuroblast | increased number | larval stage phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407 has type II neuroblast | increased number phenotype, non-suppressible by UQCR-14L^GD9481, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Suppressor of

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}/Scer\GAL4^Mhc.PW is a suppressor of wing | progressive phenotype of Pink1^B9

(Lee et al., 2013)

Other

Statement

Reference

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^NP5130, ct^HMS00924 has Malpighian tubule phenotype

(Xu et al., 2018)

N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^NP5130, ct^HMS00924 has enterocyte | ectopic phenotype

(Xu et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of ct^HMS00924 and N^{UAS.Tag:V5,Tag:polyHis} under the control of Scer\GAL4^esg-NP5130 leads to the abnormal differentiation of renal tubule progenitors into enterocyte-like cells (i.e. Pdm1-positive cells).

(Xu et al., 2018)

The increased number of neuroblasts in third instar larval brains resulting from the expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407 is fully suppressed by the co-expression of Cdk9^{D199N.Scer\UAS.SR} alone, but only partially suppressed by the combined co-expression of Cdk9^{D199N.Scer\UAS.SR} and E(spl)mγ-HLH^Scer\UAS.cLb.

(Liu et al., 2017)

Co-expression of ban^{sponge.Scer\UAS.T:Disc\RFP} (but not of both ban^{sponge.Scer\UAS.T:Disc\RFP} and numb^HMS01459, or both ban^{sponge.Scer\UAS.T:Disc\RFP} and Myc^Scer\UAS.cZa, or both ban^{sponge.Scer\UAS.T:Disc\RFP} and CG8184^HMS01605 or a combination of expression of ban^{sponge.Scer\UAS.T:Disc\RFP} and the presence of numb¹⁵/+) leads to partial suppression of the ectopic neuroblast formation and increased neuroblast numbers seen in larval brains expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

The presence of pros¹⁷/+ or brat^k06028/+, or the co-expression of CycE^Scer\UAS.cLa, does not change the number of neuroblasts per brain lobe seen in larval brains expressing both ban^{sponge.Scer\UAS.T:Disc\RFP} and N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Co-expression of numb^HMS01459 or presence of numb¹⁵/+ fails to suppress the increased neuroblast number seen in larval brains expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Co-expression of ban^{D.Scer\UAS.T:Avic\GFP-EGFP} leads to enhancement of the ectopic neuroblast formation and increased neuroblast number phenotypes seen in larval brains expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

(Wu et al., 2017)

Co-expression of either Drp1^{K38A.Scer\UAS.T:Ivir\HA1}, srl^HMS00857, ND75^NIG.2286R, rictor^JF01086 or Akt1^HMS00007 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Co-expression of either CG17856^GD9481 or trc^{K122A+T453A.Scer\UAS} does not suppress the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^Mhc.PW suppresses the abnormal wing posture of Pink1^B9 flies.

Expression of N^GD14477 under the control of Scer\GAL4^Mhc.PW does not suppress the abnormal wing posture of Pink1^B9 flies.

Co-expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} suppresses the aggregation of mitochondria seen in the indirect flight muscles of animals expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Simultaneous co-expression of both Pink1^{dsRNA.Scer\UAS} and Su(H)^HM05110 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Simultaneous co-expression of both Pink1^{dsRNA.Scer\UAS} and dm^KK103869 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Co-expression of either Pink1^Scer\UAS.cYa or rictor^Scer\UAS.cHa enhances the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^pnt-14-94.

(Lee et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

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Wild-type

Stocks (0)

Notes on Origin

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Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6}

N^{UAS.Tag:V5,Tag:polyHis}

Name Synonyms

Secondary FlyBase IDs

References (10)

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