FlyBase Allele Report: Dmel\cindr[dsRNA.PC.PD.UAS]

General Information

Symbol

Dmel\cindr^{dsRNA.PC.PD.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0243994

Feature type

allele

Associated gene

Dmel\cindr

Associated Insertion(s)

Carried in Construct

P{UAS-cindr-PC-PD.IR}

Also Known As

UAS-cindr^RNAi2.21+23, cindr-IR²

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Johnson et al., 2008)

in vitro construct - regulatory fusion

(Johnson et al., 2008)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-cindr-PC-PD.IR}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of an inverted repeat (IR) that specifically targets the long (PC) and intermediate (PD) isoforms of cindr.

(Johnson et al., 2008)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

cindr

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

increased cell number | pupal stage

(Martín-Bermudo et al., 2015)

lethal | embryonic stage, with Scer\GAL4^Tub.PU

(Johnson et al., 2008)

lethal | first instar larval stage, with Scer\GAL4^Tub.PU

(Johnson et al., 2008)

planar polarity defective, with Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Phenotype Manifest In

actin cytoskeleton, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

(Johnson et al., 2008)

border follicle cell, with Scer\GAL4³⁰⁶

(Quinones et al., 2010)

cone cell, with Scer\GAL4^GMR.PF

(Johnson et al., 2008)

cone cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

(Johnson et al., 2012)

eye | pupal stage, with Scer\GAL4^GMR.PF

(Johnson and Cagan, 2009)

follicle cell, with Scer\GAL4^GR1, cindr^dsRNA.UAS

(Haglund et al., 2010)

intercellular bridge, with Scer\GAL4^GR1, cindr^dsRNA.UAS

(Haglund et al., 2010)

interommatidial precursor cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

(Johnson et al., 2012)

macrochaeta, with Scer\GAL4^ap-md544

(Johnson et al., 2008)

ommatidium, with Scer\GAL4^GMR.PF

(Johnson et al., 2011, Johnson et al., 2008)

ommatidium | somatic clone, with Scer\GAL4^FRT.Act5C

(Johnson et al., 2008)

ommatidium | somatic clone, with Scer\GAL4^FRT.Act5C, cindr^dsRNA.UAS

(Johnson et al., 2008)

pigment cell, with Scer\GAL4^GMR.PF

(Johnson et al., 2008)

primary pigment cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

(Johnson et al., 2012, Johnson et al., 2008)

primary pigment cell | pupal stage | supernumerary, with Scer\GAL4^GMR.PU

(Martín-Bermudo et al., 2015)

retina | pupal stage, with Scer\GAL4^GMR.PU

(Martín-Bermudo et al., 2015)

secondary pigment cell, with Scer\GAL4^GMR.PF

(Johnson et al., 2008)

tertiary pigment cell, with Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Detailed Description

Statement

Reference

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in a perturbed ommatidial lattice and patterning defects in the pupal retina, the number of primary pigment cells is also mildly increased.

(Martín-Bermudo et al., 2015)

Co-expression of cindr^{dsRNA.Scer\UAS} and cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in defects in the position and shape of interommatidial precursor cells, primary primary pigment cells and cone cells.

(Johnson et al., 2012)

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PF leads to multiple errors in the final arrangement of ommatidial cells.

(Johnson et al., 2011)

Co-expression of cindr^{dsRNA.PC.PD.Scer\UAS} and cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GR1 results in a significant increase in the number of binucleate follicle cells compared to control egg chambers. The increase in binucleate follicle cells is accompanied by a significant decrease in the average number of follicle cell intercellular bridges per nucleus.

(Haglund et al., 2010)

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4³⁰⁶ results in a weak border cell migration defect in the egg chamber.

Border cells expressing cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4³⁰⁶ show a slightly reduced rate of uptake of the lipophilic dye FM4-64 compared to wild-type controls.

(Quinones et al., 2010)

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} driven by Scer\GAL4^GMR.PF results in patterning defect in pupal eyes.

(Johnson and Cagan, 2009)

Ubiquitous expression of cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^tub leads to embryonic and early larval lethality.

Expression of cindr^{dsRNA.Scer\UAS} and cindr^{dsRNA.PC.PD.Scer\UAS} in the eye for at least 24 hours (under the control of Scer\GAL4^GMR.PF) does not generate any developmental defects.

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} in the eye for at least 24 hours (under the control of Scer\GAL4^GMR.PF) does not generate any developmental defects.

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} in the pupal eye (under the control of Scer\GAL4^GMR.PF) results in misplacement of cells, misorientation of pattern elements within the ommatidial field, and a variable number of pigment cells. An additional one to two pigment cells surround approximately 46% of Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} ommatidia. The most posterior fifth of Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} retinae show more severe defects: 81% of ommatidia exhibit a shortfall of one to five surround interommatidial precursor cells). Patterning of the interommatidial precursor cells is delayed or lost in these flies.

Initial recruitment of 1[o] cells in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS}, cindr^{dsRNA.Scer\UAS} eyes commences normally and many, though not all, fledgling 1[o] cells successfully encircle a central cone cell quartet. However, these emerging 1[o] cells commonly fail to maintain their niches: 1[o] cells often lose contact with their partners, a loss typically coupled with dissolution of their shared junction. As a result, one proto-1[o] cell is often replaced by another cell to generate a new 1[o] cell. Remarkably, this instability of the 1[o]-1[o] interface continues throughout the stages of interommatidial precursor cell patterning hours after 1[o] cells have normally completed their movements.

A failure to maintain proper position and stable junctions is seen in the emerging arrays of 2[o] and 3[o] pigment cells in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutant retinae. Excessive switching of cell-cell contacts, severe alterations in apical cell profiles and a failure of interommatial precursor cells to stably rearrange stepwise into single file is observed in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutant developing eyes. The result is a failure to achieve coherent patterning.

Small clonal patches of 1[o] cells expressing cindr^{dsRNA.PC.PD.Scer\UAS} and cindr^{dsRNA.Scer\UAS} under the control of Scer\GAL4^{Scer\FRT.Act5C} are consistently smaller than their wild-type neighbours. Paired cindr^{dsRNA.PC.PD.Scer\UAS} 1[o] cells frequently retract, permitting a neighbouring wild-type interommatidial precursor cell direct contact with the central cone cells and often leads to an ectopic third 1[o] cell.

Depletion of cindr through expression of cindr^{dsRNA.PC.PD.Scer\UAS} in the adult thorax, under the control of Scer\GAL4^ap-md544 results in macrochaetea that are missing, hooked, twisted, thickened, or stunted.

Strongly reducing cindr activity (in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS}, cindr^{dsRNA.Scer\UAS} mutants) has a marked effect on F-actin during interommatidial precursor cell patterning: at 28 hours APF, the density of F-actin fibrils and spikes filling the cytoplasm of interommatidial precursor cells is markedly increased. At later stages of patterning, a more dense and disorganized cytoskeletal network is observed in interommatidial precursor cells and the radiating arrangement of actin fibrils in 1[o] cells absent at 41 hours APF. Within cone cells, F-actin levels are mildly elevated at 28 hours APF, and distinct F-actin spikes fail to radiate from cell membranes.

(Johnson et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by cpa^scrd1/cpa[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by cpb[+]/cpb^6.15

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by cpb^F19/cpb[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by tsr[+]/tsr^N96A

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by tsr^N121/tsr[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by chic[+]/chic²²¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by Abl²/Abl[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by WASp[+]/WASp³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by Rho1^72R/Rho1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by Rac1^J11/Rac2^Δ/Mtl[+]/Mtl^Δ/Rac2[+]/Rac1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, enhanceable by cpa[+]/cpa^scrd2

(Johnson et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by Arp3^EP3640

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has planar polarity defective phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, cindr^{dsRNA.PC.PD.UAS} has retina | pupal stage phenotype, enhanceable by Vav²/Vav[+]

(Martín-Bermudo et al., 2015)

Scer\GAL4^GMR.PU, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell | supernumerary | pupal stage phenotype, enhanceable by Vav²/Vav[+]

(Martín-Bermudo et al., 2015)

Scer\GAL4^GMR.PU, cindr^{dsRNA.PC.PD.UAS} has retina | pupal stage phenotype, enhanceable by Vav³/Vav[+]

(Martín-Bermudo et al., 2015)

Scer\GAL4^GMR.PU, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell | supernumerary | pupal stage phenotype, enhanceable by Vav³/Vav[+]

(Martín-Bermudo et al., 2015)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}, cindr^dsRNA.UAS has interommatidial precursor cell phenotype, enhanceable by Cbl^F165/Cbl[+]

(Johnson et al., 2012)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}, cindr^dsRNA.UAS has primary pigment cell phenotype, enhanceable by Cbl^F165/Cbl[+]

(Johnson et al., 2012)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}, cindr^dsRNA.UAS has cone cell phenotype, enhanceable by Cbl^F165/Cbl[+]

(Johnson et al., 2012)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by ArfGAP3^e01250/CG6838[+]

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Asap^KG03963/CG30372[+]

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by siz^T1510/siz[+]

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by siz^T1032/siz[+]

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Efa6^KO1/CG31158[+]

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by CG31158[+]/Efa6^c00953

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Arf51F[+]/Arf51F^ΔKG1

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Arf51F[+]/Arf51F^KG02753

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Arf51F[+]/Arf51F^EP2612

(Johnson et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has eye | pupal stage phenotype, enhanceable by ena[+]/ena^GC1

(Johnson and Cagan, 2009)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by cpa^scrd1/cpa[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by cpa^scrd1/cpa[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by cpa^scrd1/cpa[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by cpb[+]/cpb^6.15

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by cpb[+]/cpb^6.15

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by cpb[+]/cpb^6.15

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by cpb^F19/cpb[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by cpb^F19/cpb[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by cpb^F19/cpb[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by tsr[+]/tsr^N96A

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by tsr[+]/tsr^N96A

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by tsr[+]/tsr^N96A

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by tsr^N121/tsr[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by tsr^N121/tsr[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by tsr^N121/tsr[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by chic[+]/chic²²¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by chic[+]/chic²²¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by chic[+]/chic²²¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Abl²/Abl[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by Abl²/Abl[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by Abl²/Abl[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by WASp[+]/WASp³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by WASp[+]/WASp³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, enhanceable by shg[+]/shg^R69

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by WASp[+]/WASp³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Rho1^72R/Rho1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by Rho1^72R/Rho1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by Rho1^72R/Rho1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by Rac1^J11/Rac2^Δ/Mtl[+]/Mtl^Δ/Rac2[+]/Rac1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by Rac1^J11/Rac2^Δ/Mtl[+]/Mtl^Δ/Rac2[+]/Rac1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by Rac1^J11/Rac2^Δ/Mtl[+]/Mtl^Δ/Rac2[+]/Rac1[+]

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, enhanceable by cpa[+]/cpa^scrd2

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, enhanceable by cpa[+]/cpa^scrd2

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has cone cell phenotype, enhanceable by cpa[+]/cpa^scrd2

(Johnson et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible | partially by ArfGAP3^d00510, Scer\GAL4^GMR.PF

(Johnson et al., 2011)

Scer\GAL4³⁰⁶, cindr^{dsRNA.PC.PD.UAS} has border follicle cell phenotype, suppressible by mim^null

(Quinones et al., 2010)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, suppressible by hbs⁴⁵⁹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, suppressible by In(1)rst³

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, suppressible by rst⁶

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by Arp3^EP3640

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by Arp3^EP3640

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by Arp3^EP3640

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has tertiary pigment cell phenotype, suppressible by Scer\GAL4^GMR.PF, shg^UAS.sgGFP/Scer\GAL4^GMR.PF

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has primary pigment cell phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has ommatidium phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has pigment cell phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS} has secondary pigment cell phenotype, suppressible by hbs³⁶¹

(Johnson et al., 2008)

Suppressor of

Statement

Reference

Scer\GAL4³⁰⁶/cindr^{dsRNA.PC.PD.UAS} is a suppressor of border follicle cell phenotype of mim^null

(Quinones et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The patterning defects and mild supernumerary primary pigment cells phenotype observed in pupal retina of flies expressing cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PU can be significantly enhanced by combination with either Vav² or Vav³ in heterozygous state.

(Martín-Bermudo et al., 2015)

Cbl^F165/+ enhances the mis-patterning of interommatidial precursor cells, primary primary pigment cells and cone cells caused by co-expression of cindr^{dsRNA.Scer\UAS} and cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Johnson et al., 2012)

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly increased in ArfGAP3^e01250 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly increased in Asap1^KG03963 heterozygotes.

Overexpression of ArfGAP3^d00510 partially suppresses the ommatidial patterning defects resulting from th expression of cindr^{dsRNA.PC.PD.Scer\UAS} driven by Scer\GAL4^GMR.PF.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in siz^T1510 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in siz^T1032 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Efa6^KO1 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Efa6^c00953 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Arf51F^ΔKG1 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Arf51F^KG02753 heterozygotes.

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Arf51F^EP2612 heterozygotes.

(Johnson et al., 2011)

Expression of cindr^{dsRNA.PC.PD.Scer\UAS} under the control of Scer\GAL4³⁰⁶ in a mim^null background restores the ability of border cells in the egg chamber to migrate.

(Quinones et al., 2010)

The pupal eye patterning defect phenotype caused by the expression of cindr^{dsRNA.PC.PD.Scer\UAS} driven by Scer\GAL4^GMR.PF is enhanced by ena^GC1/+.

(Johnson and Cagan, 2009)

The Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mispatterning phenotype is enhanced in a heterozygous shg^R69 background. In addition, large patches of black tissue are observed in the eyes of 68.3% of these adult flies; this is a significant enhancement of the penetrance and extent of degenerative tissue that is observed in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutant flies (12.6%).

Ectopic expression of shg^{Scer\UAS.T:Avic\GFP-rs} strongly suppresses the Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mispatterning phenotype and reduces the distance between interommatidial precursor cells.

Pupae heterozygous for hbs³⁶¹, hbs⁴⁵⁹, In(1)rst³, or rst⁶ exhibit mild but consistent suppression of the Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} phenotype. The prevalence of cone and 1[o] cell defects is decreased and the number of 2[o] and 3[o] cells is reduced to slightly below normal.

A cpa^scrd2 background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A cpa^scrd1 background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A cpb^6.15 background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A cpb^F19 background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A tsr^N96A heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A tsr^N121 heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A chic²²¹ heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

An Abl² heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A WASp³ heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A Df(3R)3450 heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A Rho1^72R heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

A Rac1^J11 Rac2^Δ Mtl^Δ heterozygous background enhances the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

Ectopic expression of Arp66B^EP3640 suppresses the patterning defects found in Scer\GAL4^GMR.PF>cindr^{dsRNA.PC.PD.Scer\UAS} mutants. The mean interommatidial precursor cell number and the number of cone and/or 1[o] cell errors is increased in these double mutants.

(Johnson et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

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Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cindr^{dsRNA.PC.PD.Scer\UAS}

cindr^{dsRNA.PC.PD.UAS}

Name Synonyms

Secondary FlyBase IDs

References (9)

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