FB2025_01 , released February 20, 2025
Allele: Dmel\timeoutRNAi.UAS
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General Information
Symbol
Dmel\timeoutRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0244001
Feature type
allele
Associated gene
Dmel\timeout
Associated Insertion(s)
Carried in Construct
P{UAS-timeout.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Benna et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Benna et al., 2010)
Mutagen
in vitro construct
(Benna et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-timeout.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a fragment encoding a region common to all timeout mRNA isoforms.

(Benna et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
timeout
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Act5C.PI-driven expression of timeoutdsRNA.Scer\UAS results in lethality in late pupal stages, with head and eyes more affected than either thorax or abdomen.

      Down-regulation of timeout by expression of timeoutdsRNA.Scer\UAS driven by either of the drivers Scer\GAL4elav.PLu, Scer\GAL4tim.PE, Scer\GAL4P2.4.Pdf, Scer\GAL4ey-OK107, Scer\GAL4NP6298, Scer\GAL4NP1086 or Scer\GAL4GMR.PU does not affect adult circadian locomotor activity in constant darkness.

      Circadian light entrainment is different from controls as a result of the expression of timeoutdsRNA.Scer\UAS driven by either Scer\GAL4P2.4.Pdf or Scer\GAL4NP1086.

      (Benna et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      timeoutRNAi.UAS
      timeoutdsRNA.Scer\UAS
      timeoutdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)