FlyBase Allele Report: Dmel\Rok[VDRC.cUa]

General Information

Symbol

Dmel\Rok^VDRC.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0244145

Feature type

allele

Associated gene

Dmel\Rok

Associated Insertion(s)

Carried in Construct

P{VDRC.Rok.U}

Key Links

Transgenic product class

RNAi_reagent

(Xu et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Xu et al., 2008)

Mutagen

in vitro construct

(Xu et al., 2008)

Progenitor genotype

Carried in construct

P{VDRC.Rok.U}

Cytology

Description

UAS regulatory sequences drive expression of a Rok RNAi construct.

(Xu et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rok

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

Phenotype Manifest In

egg chamber | conditional, with Scer\GAL4^hs.PU

(He et al., 2010)

presumptive embryonic salivary gland, with Scer\GAL4^arm.PS

(Xu et al., 2008)

wing, with Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

Detailed Description

Statement

Reference

Flies expressing Rok^VDRC.cUa under the control of Scer\GAL4^nub-AC-62 have small wings compared to controls.

(Rauskolb et al., 2014)

Expression of rok^VDRC.cUa in developing egg chambers under the control of Scer\GAL4^hs.PU results in rounded egg chamber morphology.

(He et al., 2010)

Salivary gland invagination and migration defects are seen in embryos expressing rok^VDRC.cUa under the control of Scer\GAL4^arm.PS.

(Xu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rok^VDRC.cUa, Scer\GAL4^nub-AC-62 has visible phenotype, enhanceable by jub^E1

(Rauskolb et al., 2014)

Suppressed by

Statement

Reference

Rok^VDRC.cUa, Scer\GAL4^nub-AC-62 has visible phenotype, suppressible by sqh^{E20E21.UAS.Tag:FLAG}, Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rok^VDRC.cUa, Scer\GAL4^nub-AC-62 has wing phenotype, enhanceable by jub^E1

(Rauskolb et al., 2014)

Suppressed by

Statement

Reference

Rok^VDRC.cUa, Scer\GAL4^nub-AC-62 has wing phenotype, suppressible by sqh^{E20E21.UAS.Tag:FLAG}, Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

NOT Suppressor of

Statement

Reference

Rok^VDRC.cUa, Scer\GAL4^nub-AC-62 is a non-suppressor of wing disc posterior compartment phenotype of Scer\GAL4^nub-AC-62, wts^VDRC.cUa

(Rauskolb et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of sqh^{E20E21.Scer\UAS.T:Zzzz\FLAG} suppresses the wing size phenotype seen in flies expressing Rok^VDRC.cUa under the control of Scer\GAL4^nub-AC-62.

Expression of Rok^VDRC.cUa does not suppress the wing disc posterior compartment overgrowth seen in flies expressing wts^VDRC.cUa under the control of Scer\GAL4^nub-AC-62.

One copy of jub^E1 enhances the reduction in wing size seen in flies expressing Rok^VDRC.cUa under the control of Scer\GAL4^nub-AC-62.

(Rauskolb et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rok^VDRC.cUa

rok^RNAi

(Tsoumpekos et al., 2018)

rok^VDRC.cUa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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