FB2025_01 , released February 20, 2025
Allele: Dmel\DriceΔ2C8
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General Information
Symbol
Dmel\DriceΔ2C8
Species
D. melanogaster
Name
FlyBase ID
FBal0244162
Feature type
allele
Associated gene
Dmel\Drice
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kondo et al., 2006)
Mutagen
P-element activity
(Kondo et al., 2006)
Progenitor genotype
P{EP}DriceGE28489
(Kondo et al., 2006)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion of the entire Ice open reading frame.

(Kondo et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Developmental apoptosis is greatly reduced in embryos that are maternally and zygotically mutant for IceΔ2C8.

      Developmental apoptosis is greatly reduced in homozygous third instar eye discs.

      γ-ray induced apoptosis (which is is seen in wild-type third larval instar wing discs after irradiation with 40Gy of γ-rays) is completely suppressed in IceΔ2C8 homozygotes. Recovery from G[[2]] arrest after irradiation occurs much earlier in the homozygotes compared to controls.

      (Kondo et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      DriceΔ2C8/DriceΔ2C8 is a suppressor of eye phenotype of hidGMR.PG

      (Kondo et al., 2006)

      DriceΔ2C8/DriceΔ2C8 is a suppressor of eye disc phenotype of hidGMR.PG

      (Kondo et al., 2006)
      NOT Suppressor of
      Statement
      Reference

      DriceΔ2C8/DriceΔ2C8 is a non-suppressor of wing disc phenotype of BacA\p35UAS.cHa, Scer\GAL4hh-Gal4, rprUAS.cUa

      (Kondo et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Developmental apoptosis in the eye disc is completely absent in Dcp-1Prev1 ; IceΔ2C8 double homozygous third instar larvae.

      The reduction in adult eye size caused by expression of WGMR.PG is suppressed in a IceΔ2C8/IceΔ2C8 background.

      The apoptosis posterior to the morphogenetic furrow that is induced by WGMR.PG in third larval instar eye discs is almost completely suppressed in a IceΔ2C8/IceΔ2C8 background.

      The accelerated recovery from G[[2]] arrest which is seen in IceΔ2C8 wing discs after irradiation with 40Gy of γ-rays is suppressed if the animals are also homozygous for NcΔA8.

      (Kondo et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of BacA\p35Scer\UAS.cHa and rprScer\UAS.cUa in the posterior compartment of the wing disc under the control of Scer\GAL4hh-Gal4 induces dramatic tissue overgrowth. This tissue overgrowth is not suppressed by IceΔ2C8/IceΔ2C8.

      (Kondo et al., 2006)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DriceΔ2C8
      (Schott et al., 2017)
      IceΔ2C8
      driceΔ2C8
      (Shinoda et al., 2023, Kondo et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)