FB2025_01 , released February 20, 2025
Allele: Dmel\Traf43
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General Information
Symbol
Dmel\Traf43
Species
D. melanogaster
Name
FlyBase ID
FBal0244167
Feature type
allele
Associated gene
Dmel\Traf4
Associated Insertion(s)
TI{TI}Traf43
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Mathew et al., 2009)
I-SceI
(Mathew et al., 2009)
FLPase
(Mathew et al., 2009)
ends-out gene targeting
(Mathew et al., 2009)
Progenitor genotype
Associated Insertion(s)
TI{TI}Traf43
Cytology
Description

Approximately 4kb of the Traf4 sequence from exon 2 onwards have been replaced by a w+mW.hs marker. This removes the large Zinc-finger and MATH-domain encoding exon.

(Mathew et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos die during late embryonic or early larval stages with no evident morphological defects. The embryos often show a delay in ventral furrow formation at stages 6 and 6b. Embryos derived from homozygous germline clones show the same phenotype, but with a higher penetrance. In addition, 29.4% of fertilised embryos derived from homozygous germline clones fail to hatch. They show variable cuticle defects (43% ventral holes, 29% dorsal closure defects, 19% head defects and 9% non-specific defects).

      (Mathew et al., 2011)

      Homozygous Traf4Δ.w and Traf4Δ.w/Df(2L)ed-dp embryos show delays in ventral furrow formation.

      Homozygous Traf43 and Traf43/Df(2L)ed-dp embryos show delays in ventral furrow formation.

      (Mathew et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Traf4[+]/Traf43 is an enhancer of visible phenotype of Scer\GAL4en.PU, armUAS.cWa

      (Mathew et al., 2011)
      Suppressor of
      Statement
      Reference

      Traf4[+]/Traf43 is a suppressor | partially of visible phenotype of Scer\GAL4en.PU, shgi.UAS.Tag:SS(aos),Tag:MYC

      (Mathew et al., 2011)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Traf43 has ventral furrow phenotype, enhanceable by arm3/arm[+]

      (Mathew et al., 2011)
      Enhancer of
      Statement
      Reference

      Traf4[+]/Traf43 is an enhancer of wing margin bristle | ectopic phenotype of Scer\GAL4en.PU, armUAS.cWa

      (Mathew et al., 2011)
      Suppressor of
      Statement
      Reference

      Traf4[+]/Traf43 is a suppressor | partially of wing blade phenotype of Scer\GAL4en.PU, shgi.UAS.Tag:SS(aos),Tag:MYC

      (Mathew et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The delays in ventral furrow formation seen in homozygous Traf43 embryos are more severe if they are derived from females heterozygous for arm4.

      The ectopic wing margin bristle phenotype caused by expression of armScer\UAS.cWa under the control of Scer\GAL4en.PU is enhanced by Traf43/+.

      The loss of wing blade caused by expression of aos::shgi.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4en.PU is partially suppressed by Traf43/+.

      (Mathew et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Traf43
      (Mathew et al., 2011)
      Traf4Δ.w
      traf43
      (Mathew et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)