FB2021_01, released Feb 18, 2021

Allele: Dmel\foxoUAS.Tag:FLAG

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General Information
Symbol
Dmel\foxoUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0244195
Feature type
allele
Associated gene
Dmel\foxo
Associated Insertion(s)
Carried in Construct
P{UAS-foxo.FLAG}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Nielsen et al., 2008)
in vitro construct - coding region fusion
(Nielsen et al., 2008)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-foxo.FLAG}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of a Tag:FLAG-tagged foxo.

      (Nielsen et al., 2008)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      foxo
      Tagged with
      Tag:FLAG
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of foxoScer\UAS.T:Zzzz\FLAG driven by Scer\GAL4GMR.PF induces excessive apoptosis in the developing retina resulting in significant ablation of adult ommatidial structures.

      Scer\GAL4Ilp2.PR induced expression of foxoScer\UAS.T:Zzzz\FLAG results in a small body size phenotype.

      Scer\GAL4ppl.PP induced expression of foxoScer\UAS.T:Zzzz\FLAG results in a small body size phenotype.

      (Nielsen et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, foxoUAS.Tag:FLAG has eye phenotype, enhanceable by 14-3-3εj2B10/14-3-3epsilon[+], Scer\GAL4GMR.PF

      (Nielsen et al., 2008)
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye phenotype resulting from the overexpression of foxoScer\UAS.T:Zzzz\FLAG driven by Scer\GAL4GMR.PF is strongly enhanced in a heterozygous 14-3-3εj2B10 genetic background.

      The eye phenotype resulting from the overexpression of foxoScer\UAS.T:Zzzz\FLAG driven by Scer\GAL4GMR.PF is suppressed by 14-3-3εEP3578 or 14-3-3εScer\UAS.cCa overexpression.

      The Scer\GAL4Ilp2.PR-driven foxoScer\UAS.T:Zzzz\FLAG-overexpression induced small body size phenotype is suppressed by the co-overexpression of 14-3-3εScer\UAS.cCa.

      The Scer\GAL4ppl.PP-driven foxoScer\UAS.T:Zzzz\FLAG-overexpression induced small body size phenotype is suppressed by the co-overexpression of 14-3-3εScer\UAS.cCa.

      (Nielsen et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      foxoScer\UAS.T:Zzzz\FLAG
      foxoUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)