Allele Dmel\kibra^{Scer\UAS.P\T.cYa}

General Information
Symbol	Dmel\kibra^{Scer\UAS.P\T.cYa}	Species	D. melanogaster
Name		FlyBase ID	FBal0244408
Feature type	allele	Associated gene	Dmel\kibra

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Yu et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory and P\T promoter sequences drive expression of the kibra RE26350 cDNA clone. (Yu et al., 2010)
Carried in construct	P{UASp-kibra.Y} (Yu et al., 2010, Yu et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death, with Scer\GAL4^GMR.PF (Yu et al., 2010) visible, with Scer\GAL4^GMR.PF (Yu et al., 2010, Yu et al., 2010)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PF (Yu et al., 2010, Yu et al., 2010) eye disc, with Scer\GAL4^GMR.PF (Yu et al., 2010)
Detailed Description
	Statement Reference Expression of kibra[Scer\UAS.P\T.cYa] under the control of Scer\GAL4[GMR.PF] results in ectopic apoptosis in the eye imaginal disc and adults with smaller eyes than normal. (Yu et al., 2010) Expression of kibra[Scer\UAS.P\T.cYa] under the control of Scer\GAL4[GMR.PF] results in a reduction in the size of the adult eye. (Yu et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, kibra^{Scer\UAS.P\T.cYa} has increased cell death phenotype, suppressible \| somatic clone by sav^shrp-1/sav^shrp-1 (Yu et al., 2010) Scer\GAL4^GMR.PF, kibra^{Scer\UAS.P\T.cYa} has visible phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF (Yu et al., 2010)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, kibra^{Scer\UAS.P\T.cYa} has eye phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF (Yu et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of kibra[Scer\UAS.P\T.cYa] and yki[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] results in an eye size similar to that caused by expression of yki[Scer\UAS.cHa] alone under the control of Scer\GAL4[GMR.PF]. Homozygous sav[shrp-1] eyes (induced by the eyFLP method) that are also expressing kibra[Scer\UAS.P\T.cYa] under the control of Scer\GAL4[GMR.PF] show overgrowth similar to that seen in eyes that are mutant for sav[shrp-1] alone. In the eye discs of these animals, the ectopic cell death that is induced by expression of kibra[Scer\UAS.P\T.cYa] under the control of Scer\GAL4[GMR.PF] in a wild-type background is suppressed in the sav[shrp-1] clones. (Yu et al., 2010)
Xenogenetic Interactions
Statement Reference The reduction in eye size caused by expression of kibra[Scer\UAS.P\T.cYa] under the control of Scer\GAL4[GMR.PF] is significantly suppressed by co-expression of BacA\p35[Scer\UAS.cHa]. (Yu et al., 2010)
Complementation & Rescue Data
Rescues	Scer\GAL4^Act.PU/kibra^{Scer\UAS.P\T.cYa} rescues kibra^del (Yu et al., 2010)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	kibra^{Scer\UAS.P\T.cYa}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Yu et al., 2010, Dev. Cell 18(2): 288--299 Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded. [FBrf0210017]
Supplementary material	Yu et al., 2010, Dev. Cell 18(2): Supplemental information. [FBrf0211372]

Allele Dmel\kibraScer\UAS.P\T.cYa

Allele Dmel\kibra^{Scer\UAS.P\T.cYa}