FB2025_01 , released February 20, 2025
Allele: Dmel\EG28EG28
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General Information
Symbol
Dmel\EG28EG28
Species
D. melanogaster
Name
FlyBase ID
FBal0244438
Feature type
allele
Associated gene
EG28
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ma et al., 2009)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      EG28EG28/EG28[+] is an enhancer of abnormal neurophysiology | adult stage | dominant phenotype of DCTN1-p150Gl-1

      (Ma et al., 2009)

      EG28EG28/EG28[+] is an enhancer of visible phenotype of DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2009)
      NOT Enhancer of
      Statement
      Reference

      EG28EG28/EG28[+] is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307

      (Ma et al., 2009)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      EG28EG28/EG28[+] is an enhancer of eye phenotype of DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2009)
      NOT Enhancer of
      Statement
      Reference

      EG28EG28/EG28[+] is a non-enhancer of giant fiber neuron phenotype of DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307

      (Ma et al., 2009)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      EG28EG28 dominantly enhances the eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF.

      20% of giant fiber axons fail to exit the brain in adults expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307 in a EG28EG28/+ background.

      Only 3% of giant fiber axons in Gl1/+ ; EG28EG28/+ double heterozygotes lack the characteristic terminal bend, but the axons often show ectopic branching.

      The electrophysiological defects seen in the giant fiber system of Gl1/+ adults are enhanced if they are also heterozygous for EG28EG28; the response latencies are significantly increased and the double heterozygous flies show poor following.

      (Ma et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      It has not been determined whether the lethality of the chromosome is caused by the mutation that modifies the eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF, so it is possible that the recessive lethality of the chromosome is due to a second-site mutation.

      (Ma et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      EG28EG28
      Name Synonyms
      Secondary FlyBase IDs
        References (1)