Allele Dmel\EG28^EG28

General Information
Symbol	Dmel\EG28^EG28	Species	D. melanogaster
Name		FlyBase ID	FBal0244438
Feature type	allele	Associated gene	Dmel\EG28

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Ma et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Ma et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference EG28^EG28/EG28[+] is an enhancer of neurophysiology defective \| dominant \| adult stage phenotype of Gl¹ (Ma et al., 2009) EG28^EG28/EG28[+] is an enhancer of visible phenotype of Gl^Δ.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Ma et al., 2009)
NOT Enhancer of
Statement Reference EG28^EG28/EG28[+] is a non-enhancer of neuroanatomy defective \| adult stage phenotype of Gl^Δ.Scer\UAS, Scer\GAL4^A307 (Ma et al., 2009)
Other
Statement Reference EG28^EG28/EG28[+], Gl¹ has neuroanatomy defective \| dominant \| adult stage phenotype (Ma et al., 2009) EG28^EG28/EG28[+], Gl^Δ.Scer\UAS, Scer\GAL4^A307 has neuroanatomy defective \| adult stage phenotype (Ma et al., 2009)
Phenotype Manifest In
Enhancer of
Statement Reference EG28^EG28/EG28[+] is an enhancer of eye phenotype of Gl^Δ.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Ma et al., 2009)
NOT Enhancer of
Statement Reference EG28^EG28/EG28[+] is a non-enhancer of giant fiber neuron phenotype of Gl^Δ.Scer\UAS, Scer\GAL4^A307 (Ma et al., 2009)
Other
Statement Reference EG28^EG28/EG28[+], Gl¹ has giant fiber neuron phenotype (Ma et al., 2009) EG28^EG28/EG28[+], Gl^Δ.Scer\UAS, Scer\GAL4^A307 has giant fiber neuron phenotype (Ma et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference EG28[EG28] dominantly enhances the eye phenotype caused by expression of Gl[Δ.Scer\UAS] under the control of Scer\GAL4[GMR.PF]. 20% of giant fiber axons fail to exit the brain in adults expressing Gl[Δ.Scer\UAS] under the control of Scer\GAL4[A307] in a EG28[EG28]/+ background. Only 3% of giant fiber axons in Gl[1]/+ ; EG28[EG28]/+ double heterozygotes lack the characteristic terminal bend, but the axons often show ectopic branching. The electrophysiological defects seen in the giant fiber system of Gl[1]/+ adults are enhanced if they are also heterozygous for EG28[EG28]; the response latencies are significantly increased and the double heterozygous flies show poor following. (Ma et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	It has not been determined whether the lethality of the chromosome is caused by the mutation that modifies the eye phenotype caused by expression of Gl[Δ.Scer\UAS] under the control of Scer\GAL4[GMR.PF], so it is possible that the recessive lethality of the chromosome is due to a second-site mutation. (Ma et al., 2009)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	EG28^EG28
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Ma et al., 2009, BMC Genet. 10: 77 A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation. [FBrf0209456]

Allele Dmel\EG28EG28

Allele Dmel\EG28^EG28