FB2025_01 , released February 20, 2025
Allele: Dmel\TBPH1
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General Information
Symbol
Dmel\TBPH1
Species
D. melanogaster
Name
FlyBase ID
FBal0244510
Feature type
allele
Associated gene
Dmel\TBPH
Associated Insertion(s)
Carried in Construct
Also Known As
TBPHnull
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Fiesel et al., 2010)
Mutagen
P-element activity
(Fiesel et al., 2010)
Progenitor genotype
Cytology
Description

The entire TBPH coding region has been deleted by combined excision/recombination events involving the P{SUPor-P}TBPHKG08578 and P{SUPor-P}bgcnKG08129 insertions.

(Fiesel et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis
      CEA with TBPHΔ23
      (Baldwin et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TBPH1/TBPHΔ23 transheterozygotes are semi-lethal and the eclosing adults are uncoordinated, are not able to climb and die within 5 days. These mutants also show impaired larval locomotion in crawling assays, as compared to controls.

      TBPH1/TBPHΔ23 transheterozygotes show a decrease in axonal transport of mitochondria (i.e. a significant decrease in anterograde transport and a significant increase in the stationary fraction), but not of (NPY-positive) vesicles, in third instar larval motor neurons, as compared to controls.

      (Baldwin et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      TBPH1/TBPHΔ23 has partially lethal - majority die phenotype, suppressible by Hsap\TARDBPUAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\TARDBPUAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Hsap\TARDBPUAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has partially lethal - majority die phenotype, suppressible by Hsap\TARDBPM337V.UAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\TARDBPM337V.UAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Hsap\TARDBPM337V.UAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has partially lethal - majority die phenotype, suppressible by cazUAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by cazUAS.x10.Tag:FLAG/Scer\GAL4Toll-6-D42

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has partially lethal - majority die phenotype, suppressible by Scer\GAL4Toll-6-D42/cazP398L.10x.UAS.Tag:FLAG

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Scer\GAL4Toll-6-D42/cazP398L.10x.UAS.Tag:FLAG

      (Baldwin et al., 2016)
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The semi-lethality and the decreased adult climbing capacity, but not the decreased third instar larval crawling capacity,observed in TBPH1/TBPHΔ23 transheterozygotes are suppressed by the expression of either cazScer\UAS.x10.T:Zzzz\FLAG or cazP398L.10x.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Toll-6-D42. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also partially suppressed by the expression of cazP398L.10x.Scer\UAS.T:Zzzz\FLAG, but not cazScer\UAS.x10.T:Zzzz\FLAG, under the control of Scer\GAL4CCAP.PI.

      (Baldwin et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference

      The semi-lethality and the decreased third instar larval crawling capacity, but not the decreased adult climbing capacity, observed in TBPH1/TBPHΔ23 transheterozygotes are suppressed by the expression of either Hsap\TARDBPScer\UAS.x10.T:Zzzz\FLAG or Hsap\TARDBPM337V.Scer\UAS.x10.T:Zzzz\FLAG under the control of Scer\GAL4CCAP.PI. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also suppressed by the expression of either Hsap\TARDBPScer\UAS.x10.T:Zzzz\FLAG or Hsap\TARDBPM337V.Scer\UAS.x10.T:Zzzz\FLAG under the control of Scer\GAL4CCAP.PI.

      (Baldwin et al., 2016)
      Complementation and Rescue Data
      Partially rescued by

      TBPH1/TBPHΔ23 is partially rescued by Scer\GAL4Toll-6-D42/TBPHUAS.10x.Venus

      (Baldwin et al., 2016)

      TBPH1/TBPHΔ23 is partially rescued by Scer\GAL4CCAP.PU/TBPHUAS.10x.Venus

      (Baldwin et al., 2016)
      Comments

      The semi-lethality and the decreased third instar larval crawling capacity, but not the decreased adult climbing capacity, observed in TBPH1/TBPHΔ23 transheterozygotes are rescued by the expression of TBPHScer\UAS.10x.T:Avic\GFP-YFP.Venus under the control of Scer\GAL4Toll-6-D42. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also partially rescued by the expression of TBPHScer\UAS.10x.T:Avic\GFP-YFP.Venus under the control of Scer\GAL4CCAP.PI.

      (Baldwin et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      TBPH1
      (Baldwin et al., 2016)
      TBPHnull
      (Vanden Broeck et al., 2013, Fiesel et al., 2010)
      TBPHnull
      (Diaper et al., 2013)
      tbph0
      (Miskiewicz et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)