FB2025_01 , released February 20, 2025
Allele: Dmel\Nipped-BNC39
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General Information
Symbol
Dmel\Nipped-BNC39
Species
D. melanogaster
Name
FlyBase ID
FBal0244678
Feature type
allele
Associated gene
Dmel\Nipped-B
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gause et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: I1509N.

(Gause et al., 2008)

Nucleotide substitution: T4705A.

(Gause et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:4,695,509..4,695,509 [-]
Nucleotide change:

T4695509A

Reported nucleotide change:

T4705A

Amino acid change:

I1510N | Nipped-B-PE; I1510N | Nipped-B-PF; I1486N | Nipped-B-PG; I1486N | Nipped-B-PH; I1486N | Nipped-B-PI; I1390N | Nipped-B-PJ

Reported amino acid change:

I1509N

(Gause et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal mitotic cell cycle (with Nipped-B02047)

      (Gause et al., 2008)

      lethal (with Df(2R)M41A2)

      (Coulthard et al., 2010)

      lethal (with Nipped-B34-3)

      (Coulthard et al., 2010)

      lethal (with Nipped-B45-53)

      (Coulthard et al., 2010)

      lethal (with Nipped-B292.1)

      (Coulthard et al., 2010)

      lethal (with Nipped-B407)

      (Coulthard et al., 2010)

      lethal (with Nipped-B02047)

      (Coulthard et al., 2010)

      lethal (with Nipped-Bch(2)54)

      (Coulthard et al., 2010)

      lethal (with Nipped-BIR13)

      (Coulthard et al., 2010)

      lethal (with Nipped-Bk02601a)

      (Coulthard et al., 2010)

      lethal (with Nipped-BL5)

      (Coulthard et al., 2010)

      lethal (with Nipped-BL7)

      (Coulthard et al., 2010)

      lethal (with Nipped-BLa6)

      (Coulthard et al., 2010)

      lethal (with Nipped-BLf)

      (Coulthard et al., 2010)

      lethal (with Nipped-BLL)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC6)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC7)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC23)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC41)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC59)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC60)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC71)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC77)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC78)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC91)

      (Coulthard et al., 2010)

      lethal (with Nipped-BNC138)

      (Coulthard et al., 2010)

      lethal - all die before end of second instar larval stage | recessive

      (Gause et al., 2008)

      some die during second instar larval stage | recessive

      (Gause et al., 2008)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants die at the second to third instar moult.

      Neuroblast metaphase nuclei show precocious sister chromatid separation in Nipped-B02047/Nipped-BNC39 animals.

      (Gause et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nipped-B[+]/Nipped-BNC39 is an enhancer of wing margin phenotype of ctK

      (Gause et al., 2008)

      Nipped-B[+]/Nipped-BNC39 is an enhancer of adult thorax phenotype of Ubxbx-34e, su(Hw)e2

      (Gause et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NC39
      (Coulthard et al., 2010)
      Nipped-BNC39
      (Coulthard et al., 2010, Gause et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)