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General Information
Symbol
Dmel\hpo5.1
Species
D. melanogaster
Name
FlyBase ID
FBal0244706
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a 1983bp deletion that removes part of the 5'UTR, the coding start site, the whole first exon and part of the second exon of hpo.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones generated using the eyFLP system result in eyes with an increased number of interommatidial cells compared to wild type.

hpo5.1/hpo5.1 eyes (created by the EGUF method in otherwise heterozygous animals) contain significantly increased number of inter-ommatidial cells in the pupal retina compared to wild-type and the adult eyes are overgrown and misshapen with folds.

Adults containing homozygous clones represent 34.3% of the population recovered after clones are induced using the eyFLP method (expected fraction of adults containing mutant clones is 50% if there is no effect of the mutant clones on viability).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

hpo5.1 has visible | adult stage phenotype, non-suppressible by ZyxΔ41/ZyxΔ41

Suppressor of
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference
Suppressed by
Suppressor of
Statement
Reference

hpo5.1/hpo[+] is a suppressor | partially of eye phenotype of Scer\GAL4GMR.PF, kibraEP747

Additional Comments
Genetic Interactions
Statement
Reference

The increase in the number of interommatidial cells which is seen in homozygous hpo5.1 clones generated using the eyFLP system is not further enhanced if the clones are also homozygous for Gitex21C.

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for hpo5.1/hpo5.1 eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with ZyxΔ41/ZyxΔ41 but the overgrowth and folded shape of the adult eyes cannot be rescued.

hpo5.1 suppresses the ectopic apoptosis in the eye discs which is induced by expression of kibraScer\UAS.P\T.cGa under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)