FlyBase Allele Report: Dmel\ntc[ms771]

General Information

Symbol

Dmel\ntc^ms771

Species

D. melanogaster

Name

FlyBase ID

FBal0244744

Feature type

allele

Associated gene

Dmel\ntc

Associated Insertion(s)

Carried in Construct

Also Known As

Z3-4692, ms771, nutcracker^ms771

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q?term.

(Bader et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 15

CEC

(Sanchez-Martinez et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cystic bulge

(Bader et al., 2010)

sperm individualization complex

(Bader et al., 2011)

Detailed Description

Statement

Reference

ntc^ms771 mutants are sterile. The sperm individualization complex does not form and sperm fail to individualize.

(Bader et al., 2011)

Mutant spermatids have normal axonemes and mitochondrial derivatives at the individualisation stage, but the individualization complex does not form. There is a lack of caspase activation in the mutant spermatids.

(Bader et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

ntc^ms771 has sterile phenotype, non-suppressible by Scer\GAL4^Act.PU/PI31^UASp.Tag:HA

(Bader et al., 2011)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

ntc^ms771 has sperm individualization complex phenotype, non-suppressible by Scer\GAL4^Act.PU/PI31^UASp.Tag:HA

(Bader et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of PI31^{Scer\UAS.P\T.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU does not restore fertility or sperm individualization to ntc^ms771 mutants.

(Bader et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ntc^f07259

(Bader et al., 2010)

Rescued by

ntc^ms771 is rescued by Scer\GAL4^da.G32/ntc^UAS.cSa

(Sanchez-Martinez et al., 2023)

ntc^ms771 is rescued by ntc^WT.hsp83

(Bader et al., 2011)

ntc^ms771 is rescued by ntc^Hsp83.PB

(Bader et al., 2010)

Partially rescued by

ntc^ms771 is partially rescued by ntc^{dj.Tag:proteinA}

(Bader et al., 2010)

Not rescued by

ntc^ms771 is not rescued by ntc^V-E.hsp83

(Bader et al., 2011)

Comments

ntc^WT.hsp83 completely restores fertility to ntc^ms771 animals and sperm individualization complexes are normal.

ntc^V-E.hsp83 fails to restore fertility to ntc^ms771 animals and sperm individualization is incomplete.

(Bader et al., 2011)

ntc^Hsp83.PB rescues ntc^ms771 male sterility and lack of caspase activation seen in the spermatids of ntc^ms771 males.

ntc^dj.T:Saur\A rescues cleaved caspase staining and the formation of irregular individualisation complexes in the testes of ntc^ms771 males, but fails to rescue their sterility.

(Bader et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600213

ntc^ms771/TM6B, P{Ubi-GFP.S65T}PAD2, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Z3-4692

(Bader et al., 2011, Bader et al., 2010)

ms771

(Bader et al., 2011, Bader et al., 2010)

ntc^ms771

(Rodriguez et al., 2025, Sanchez-Martinez et al., 2023, Dabool et al., 2020, Bader et al., 2011)

nutcracker^ms771

(Bader et al., 2010)

Name Synonyms

nutcrackerms771

(Bader et al., 2011)

Secondary FlyBase IDs

References (5)

Report Sections

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