Allele Dmel\ntc^ms771

General Information
Symbol	Dmel\ntc^ms771	Species	D. melanogaster
Name		FlyBase ID	FBal0244744
Feature type	allele	Associated gene	Dmel\ntc
Also Known As	Z3-4692, ms771

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q?@. (Bader et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	male sterile (Bader et al., 2010) male sterile, with Df(3L)HR119 (Bader et al., 2010) male sterile (with Df(3L)Exel6097) (Bader et al., 2010) male sterile (with Df(3L)GN34) (Bader et al., 2010) male sterile (with ntc^f07259) (Bader et al., 2010) sterile (Bader et al., 2011) viable (Bader et al., 2010)
Phenotype Manifest In
	cystic bulge (Bader et al., 2010) sperm individualization complex (Bader et al., 2011)
Detailed Description
	Statement Reference ntc[ms771] mutants are sterile. The sperm individualization complex does not form and sperm fail to individualize. (Bader et al., 2011) Mutant spermatids have normal axonemes and mitochondrial derivatives at the individualisation stage, but the individualization complex does not form. There is a lack of caspase activation in the mutant spermatids. (Bader et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
NOT suppressed by
Statement Reference ntc^ms771 has sterile phenotype, non-suppressible by Scer\GAL4^Act.PU/PI31^{Scer\UAS.P\T.T:Ivir\HA1} (Bader et al., 2011)
Phenotype Manifest In
NOT suppressed by
Statement Reference ntc^ms771 has sperm individualization complex phenotype, non-suppressible by Scer\GAL4^Act.PU/PI31^{Scer\UAS.P\T.T:Ivir\HA1} (Bader et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Expression of PI31[Scer\UAS.P\T.T:Ivir\HA1] under the control of Scer\GAL4[Act.PU] does not restore fertility or sperm individualization to ntc[ms771] mutants. (Bader et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	ntc^f07259 (Bader et al., 2010)
Rescued by	ntc^ms771 is rescued by ntc^Hsp83.PB (Bader et al., 2010) ntc^ms771 is rescued by ntc^WT.hsp83 (Bader et al., 2011)
Partially rescued by	ntc^ms771 is partially rescued by ntc^dj.T:Saur\A (Bader et al., 2010)
Not rescued by	ntc^ms771 is not rescued by ntc^V-E.hsp83 (Bader et al., 2011)
Comments	ntc[WT.hsp83] completely restores fertility to ntc[ms771] animals and sperm individualization complexes are normal. ntc[V-E.hsp83] fails to restore fertility to ntc[ms771] animals and sperm individualization is incomplete. (Bader et al., 2011) ntc[Hsp83.PB] rescues ntc[ms771] male sterility and lack of caspase activation seen in the spermatids of ntc[ms771] males. ntc[dj.T:Saur\A] rescues cleaved caspase staining and the formation of irregular individualisation complexes in the testes of ntc[ms771] males, but fails to rescue their sterility. (Bader et al., 2010)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ms771 (Bader et al., 2010, Bader et al., 2011) ntc^ms771 (Bader et al., 2011) nutcracker^ms771 (Bader et al., 2010) Z3-4692 (Bader et al., 2010, Bader et al., 2011)
Name Synonym	nutcracker^ms771 (Bader et al., 2011)
Secondary FlyBase IDs

References ( 2 )
Research paper	Bader et al., 2011, Cell 145(3): 371--382 A conserved f box regulatory complex controls proteasome activity in Drosophila. [FBrf0213568] Bader et al., 2010, Development 137(10): 1679--1688 A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila. [FBrf0210629]

Allele Dmel\ntcms771

Allele Dmel\ntc^ms771