FlyBase Allele Report: Dmel\sNPF-R[UAS.cLa]

General Information

Symbol

Dmel\sNPF-R^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Lee

FlyBase ID

FBal0244779

Feature type

allele

Associated gene

Dmel\sNPF-R

Associated Insertion(s)

Carried in Construct

P{UAS-sNPF-R.L}

Also Known As

UAS-sNPFR1

Key Links

Transgenic product class

cDNA

(Lee et al., 2008)

wild_type

(Lee et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Lee et al., 2008)

wild_type

(Lee et al., 2008)

Mutagen

in vitro construct

(Lee et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-sNPF-R.L}

Cytology

Description

UAS drives expression of a full-length sNPF-R cDNA.

(Lee et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sNPF-R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior | adult stage, with Scer\GAL4^sNPF-R.2.5

(Hong et al., 2012)

increased body size, with Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing sNPF-R^Scer\UAS.cLa under the control of Scer\GAL4^sNPF-R.2.5 show significantly increased food consumption compared to controls.

(Hong et al., 2012)

Expression of sNPF-R^Scer\UAS.cLa using Scer\GAL4^MJ94 has little effect on size.

Expression of sNPF-R^Scer\UAS.cLa using Scer\GAL4^Ilp2.PR increases body size by 10%.

(Lee et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^sNPF-R.2.5, sNPF-R^UAS.cLa has abnormal feeding behavior | adult stage phenotype, suppressible by Gαs^UAS.cCa, Scer\GAL4^sNPF-R.2.5

(Hong et al., 2012)

Scer\GAL4^sNPF-R.2.5, sNPF-R^UAS.cLa has abnormal feeding behavior | adult stage phenotype, suppressible by Pka-R1^BDK.UAS, Scer\GAL4^sNPF-R.2.5

(Hong et al., 2012)

Scer\GAL4^sNPF-R.2.5, sNPF-R^UAS.cLa has abnormal feeding behavior | adult stage phenotype, suppressible by CrebB^Cbz.UAS, Scer\GAL4^sNPF-R.2.5

(Hong et al., 2012)

Scer\GAL4^sNPF-R.2.5, sNPF-R^UAS.cLa has abnormal feeding behavior | adult stage phenotype, suppressible by Scer\GAL4^sNPF-R.2.5/mnb^GD13197

(Hong et al., 2012)

NOT Suppressor of

Statement

Reference

sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR is a non-suppressor of decreased body size phenotype of Ilp2^GD15756, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR is a non-suppressor of decreased body size phenotype of Ilp1^GD2398, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The increase in food consumption compared to controls seen in adults expressing sNPF-R^Scer\UAS.cLa under the control of Scer\GAL4^sNPF-R.2.5 is suppressed by co-expression of either Gαs^Scer\UAS.cCa, Pka-R1^BDK.Scer\UAS, CrebB^Cbz.Scer\UAS or mnb^GD13197.

(Hong et al., 2012)

Co-expression of sNPF-R^Scer\UAS.cLa does not significantly affect the reduction in body size seen in Ilp1^GD2398, Scer\GAL4^Ilp2.PR or Ilp2^GD15756, Scer\GAL4^Ilp2.PR animals.

(Lee et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sNPF-R^Scer\UAS.cLa

sNPF-R^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lee

Secondary FlyBase IDs

References (3)

Report Sections

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