FB2025_02 , released April 17, 2025
Allele: Dmel\kibra1
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General Information
Symbol
Dmel\kibra1
Species
D. melanogaster
Name
FlyBase ID
FBal0244819
Feature type
allele
Associated gene
Dmel\kibra
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Baumgartner et al., 2010)
Progenitor genotype
P{EPgy2}EY03746
(Baumgartner et al., 2010)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion which removes the first exon (this includes the translation start site).

(Baumgartner et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      kibra1/kibra02404 has lethal | pupal stage phenotype, suppressible by yki[+]/ykiB5

      (Baumgartner et al., 2010)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      kibra1 has eye | somatic clone phenotype, enhanceable by exGD12782/Scer\GAL4GMR.PF

      (Baumgartner et al., 2010)

      kibra1 has eye | somatic clone phenotype, enhanceable by Scer\GAL4GMR.PF/MerGD1484

      (Baumgartner et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pupae with mosaic heads that are largely doubly mutant for exe1/exe1 and kibra1/kibra3 (clones induced using the eyFLP method without cell lethal) do not eclose and normal head structures are displaced by overgrown tissue.

      Expression of exGD12782 under the control of Scer\GAL4GMR.PF severely enhances the eye overgrowth phenotype of homozygous kibra1 eyes (generated using the eyFLP method).

      Expression of MerGD1484 under the control of Scer\GAL4GMR.PF enhances the eye overgrowth phenotype of homozygous kibra1 eyes (generated using the eyFLP method).

      exe1 kibra1 double mutant clones in the eye imaginal disc are very large and invariably adopt a rounded shape.

      (Baumgartner et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kibra1
      (Baumgartner et al., 2010, Baumgartner et al., 2010)
      kibra1
      (Albert et al., 2018, Gusareva et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)