FlyBase Allele Report: Dmel\kibra[1]

General Information

Symbol

Dmel\kibra¹

Species

D. melanogaster

Name

FlyBase ID

FBal0244819

Feature type

allele

Associated gene

Dmel\kibra

Associated Insertion(s)

Carried in Construct

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Baumgartner et al., 2010)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

P{EPgy2}EY03746

(Baumgartner et al., 2010)

Cytology

Nature of the lesion

Statement

Reference

Imprecise excision of the progenitor insertion, resulting in a deletion which removes the first exon (this includes the translation start site).

(Baumgartner et al., 2010)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal - all die before end of first instar larval stage | recessive

(Baumgartner et al., 2010)

lethal - all die before end of pupal stage (with kibra⁰²⁴⁰⁴)

(Baumgartner et al., 2010)

some die during first instar larval stage | recessive

(Baumgartner et al., 2010)

some die during pupal stage (with kibra⁰²⁴⁰⁴)

(Baumgartner et al., 2010)

visible | somatic clone

(Baumgartner et al., 2010)

Phenotype Manifest In

wing | somatic clone

(Baumgartner et al., 2010)

Detailed Description

Statement

Reference

Wings in which the posterior compartment is largely homozygous for kibra¹ are larger than control wings.

(Baumgartner et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

kibra¹ has visible | somatic clone phenotype, enhanceable by ex^GD12782/Scer\GAL4^GMR.PF

(Baumgartner et al., 2010)

kibra¹ has visible | somatic clone phenotype, enhanceable by Scer\GAL4^GMR.PF/Mer^GD1484

(Baumgartner et al., 2010)

Suppressed by

Statement

Reference

kibra¹/kibra⁰²⁴⁰⁴ has lethal | pupal stage phenotype, suppressible by yki[+]/yki^B5

(Baumgartner et al., 2010)

Other

Statement

Reference

ex^e1, kibra¹/kibra³ has lethal | somatic clone | pupal stage phenotype

(Baumgartner et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

kibra¹ has eye | somatic clone phenotype, enhanceable by ex^GD12782/Scer\GAL4^GMR.PF

(Baumgartner et al., 2010)

kibra¹ has eye | somatic clone phenotype, enhanceable by Scer\GAL4^GMR.PF/Mer^GD1484

(Baumgartner et al., 2010)

Other

Statement

Reference

ex^e1, kibra¹ has eye disc | somatic clone phenotype

(Baumgartner et al., 2010)

ex^e1, kibra¹/kibra³ has head | somatic clone | pupal stage phenotype

(Baumgartner et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Pupae with mosaic heads that are largely doubly mutant for ex^e1/ex^e1 and kibra¹/kibra³ (clones induced using the eyFLP method without cell lethal) do not eclose and normal head structures are displaced by overgrown tissue.

Expression of ex^GD12782 under the control of Scer\GAL4^GMR.PF severely enhances the eye overgrowth phenotype of homozygous kibra¹ eyes (generated using the eyFLP method).

Expression of Mer^GD1484 under the control of Scer\GAL4^GMR.PF enhances the eye overgrowth phenotype of homozygous kibra¹ eyes (generated using the eyFLP method).

ex^e1 kibra¹ double mutant clones in the eye imaginal disc are very large and invariably adopt a rounded shape.

(Baumgartner et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Kibra¹

(Baumgartner et al., 2010, Baumgartner et al., 2010)

kibra¹

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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