FB2025_01 , released February 20, 2025
Allele: Dmel\kibraΔ32
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General Information
Symbol
Dmel\kibraΔ32
Species
D. melanogaster
Name
FlyBase ID
FBal0244965
Feature type
allele
Associated gene
Dmel\kibra
Associated Insertion(s)
P{?EP}kibraΔ32
Carried in Construct
Also Known As
kib32
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Genevet et al., 2010, Genevet et al., 2010)
Progenitor genotype
P{EP}kibraEP747
(Genevet et al., 2010, Genevet et al., 2010)
Associated Insertion(s)
P{?EP}kibraΔ32
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1677bp deletion that removes part of the 5'UTR, the translation start site and a small part of the first intron of kibra. 22bp of the original insertion remains.

(Genevet et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      kibraΔ32 mutants exhibit delays in border cell migration.

      (Lucas et al., 2013)

      Homozygous clones in the retina show reduced apoptosis at 28 hours after puparium formation compared to controls.

      Homozygous clones in the eye result in eye overgrowth.

      (Genevet et al., 2010)

      Homozygous clones in the retina at 40 hours after puparium formation contain extra interommatidial cells. The apoptotic index of pupal retinas containing homozygous clones is reduced compared to wild type.

      Homozygous clones in larval imaginal discs are larger than their control twin spots.

      Eye discs containing homozygous clones show some ectopic EdU-positive staining posterior to the second mitotic wave.

      Homozygous clones result in a mutant wing phenotype.

      (Genevet et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      kibraΔ32 has abnormal cell migration phenotype, enhanceable by exAP50

      (Lucas et al., 2013)
      Suppressed by
      Enhancer of
      Statement
      Reference

      kibraΔ32 is an enhancer of abnormal cell migration phenotype of exAP50

      (Lucas et al., 2013)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      kibraΔ32 has border follicle cell phenotype, enhanceable by exAP50

      (Lucas et al., 2013)
      Suppressed by
      Enhancer of
      Statement
      Reference

      kibraΔ32 is an enhancer of border follicle cell phenotype of exAP50

      (Lucas et al., 2013)
      Other
      Statement
      Reference

      exe1, kibraΔ32/kibra[+] has follicle cell phenotype

      (Fletcher et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      exAP50,kibraΔ32 double mutants exhibit a very severe delay in border cell migration, with clusters rarely even initiating migration.

      (Lucas et al., 2013)

      exe1/exe1, kibraΔ32/+ egg chambers develop a multilayered follicle cell epithelium.

      (Fletcher et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      kib32
      (Aguilar-Aragon et al., 2020, Lucas et al., 2013)
      kibΔ32
      (Fletcher et al., 2012)
      kibraΔ32
      (Genevet et al., 2010, Genevet et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)