FB2025_01 , released February 20, 2025
Allele: Scer\GAL4NP2492
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General Information
Symbol
Scer\GAL4NP2492
Species
S. cerevisiae
Name
FlyBase ID
FBal0245082
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}NP2492
Carried in Construct
Also Known As
NP2492-GAL4, NP2492
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}NP2492
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        mushroom body vertical lobe arborizing neuron 2
        (Flybrain Neuron Database et al., 2018.6.28, Séjourné et al., 2011, Tanaka et al., 2008)
        mushroom body alpha' anterior-posterior layer
        (Tanaka et al., 2008)
        mushroom body alpha' lobe slice 3
        (Tanaka et al., 2008)
        mushroom body alpha lobe posterior layer
        (Tanaka et al., 2008)
        mushroom body alpha lobe surface layer
        (Tanaka et al., 2008)
        mushroom body alpha lobe core layer
        (Tanaka et al., 2008)
        mushroom body alpha lobe slice 2
        (Tanaka et al., 2008)
        adult lateral horn | restricted
        (Séjourné et al., 2011)
        fan-shaped body | restricted
        (Séjourné et al., 2011)
        adult olfactory receptor neuron | subset
        (Séjourné et al., 2011)
        anterior optic tubercle | restricted
        (Séjourné et al., 2011)
        posterior lateral protocerebrum | restricted
        (Séjourné et al., 2011)
        superior medial protocerebrum | restricted
        (Séjourné et al., 2011)
        ventrolateral protocerebrum | restricted
        (Séjourné et al., 2011)
        adult gnathal ganglion | restricted
        (Séjourné et al., 2011)
        Additional Information
        Statement
        Reference

        ScerGAL4NP2492 labels the mushroom body ventral lobe arborizing neuron 2. It is also expressed in other areas of the brain, including the lateral horn, fan-shaped body, protocerebrum, optic tubercle, adult olfactory receptor neurons that innervate two glomeruli in the antennal lobe and the subesophageal ganglion.

        (Séjourné et al., 2011)
         
        Marker for
        mushroom body vertical lobe arborizing neuron 2
        (Séjourné et al., 2011, Tanaka et al., 2008)
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4NP2492 cells in adults during testing does not affect the increase in aversive olfactory 24 h memory observed when the recall environment better matches the training environment (presence of copper grid), compared to controls.

        (Zhao et al., 2019)

        Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4NP2492 cells in adults does not affect startle-induced climbing behavior, compared to controls.

        Thermogenetic activation (using TrpA1UAS.(B).cKa at 32[o]C) of Scer\GAL4NP2492 cells in adults significantly reduces startle-induced climbing behavior, compared to controls.

        (Sun et al., 2018)

        Inhibition (using shi1.UAS at 33[o]C) of Scer\GAL4NP2492 cells in adults during testing significantly reduces long term (24 h after massed training) aversive olfactory memory, compared to controls.

        (Bouzaiane et al., 2015)

        Blocking synaptic transmission (using shi1.Scer\UAS at 32[o]C) from Scer\GAL4NP2492 neurons does not significantly alter naive odor avoidance behavior (to MCH at 1:1000 ), compared to controls.

        (Owald et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4NP2492
        Name Synonyms
        Secondary FlyBase IDs
          References (15)