FlyBase Allele Report: Dmel\Madm[4S3]

General Information

Symbol

Dmel\Madm^4S3

Species

D. melanogaster

Name

FlyBase ID

FBal0245108

Feature type

allele

Associated gene

Dmel\Madm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Mushtaq et al., 2022)

Mutagen

ethyl methanesulfonate

(Gluderer et al., 2010)

Progenitor genotype

Cytology

Description

Amino acid replacement: R525H.

(Gluderer et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,745,410..5,745,410 [+]

Nucleotide change:

G5745410A

Amino acid change:

R525H | Madm-PA; R525H | Madm-PB

Reported amino acid change:

R525H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Gluderer et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Madm^4S3 mutants exhibit a small head (pinhead) phenotype.

Development of Madm^4S3 mutant larvae ceases mostly in the third larval instar and in the prepupal stage. The onset of the pre-pupal stage is delayed by 2 to 10 days. Madm^4S3 mutants do not exhibit any reduction in larval size.

(Gluderer et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Thor^HMS01555/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Suppressed by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Thor²

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/mTor^HMS01114

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by GluRIIA^SP16/GluRIIA^SP16

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has abnormal neurophysiology | larval stage phenotype, suppressible by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^elav-C155/Thor^HMS01555

(Mushtaq et al., 2022)

NOT suppressed by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Thor^HMS01555/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

NOT Enhancer of

Statement

Reference

Madm^4S3 is a non-enhancer of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16

(Mushtaq et al., 2022)

NOT Suppressor of

Statement

Reference

Madm^4S3 is a non-suppressor of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16

(Mushtaq et al., 2022)

Other

Statement

Reference

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-enhanceable by GluRIIA^SP16/GluRIIA^SP16

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-enhanceable by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-enhanceable by Thor^HMS01555/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Suppressed by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Thor²

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has synapse | larval stage phenotype, suppressible | partially by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, suppressible by Scer\GAL4^elav-C155/Thor^HMS01555

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has synapse | larval stage phenotype, suppressible | partially by Thor²

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, suppressible | partially by Thor²

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has synapse | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/mTor^HMS01114

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has synapse | larval stage phenotype, suppressible | partially by GluRIIA^SP16/GluRIIA^SP16

(Mushtaq et al., 2022)

NOT suppressed by

Statement

Reference

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by GluRIIA^SP16/GluRIIA^SP16

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by Thor^HMS01555/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by mTor^UAS.Tag:MYC/Scer\GAL4^{GluRIIB-MI03631-TG4.2}

(Mushtaq et al., 2022)

NOT Enhancer of

Statement

Reference

Madm^4S3 is a non-enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16

(Mushtaq et al., 2022)

NOT Suppressor of

Statement

Reference

Madm^4S3 is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16

(Mushtaq et al., 2022)

Other

Statement

Reference

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(3R)Exel7283/Madm^4S3 is rescued by Scer\GAL4^elav-C155/Scer\GAL4^{GluRIIB-MI03631-TG4.2}/Madm^UAS.EGFP

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 is rescued by Scer\GAL4^elav-C155/Madm^UAS.EGFP

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 is rescued by Scer\GAL4^VGlut1-OK371/Madm^UAS.EGFP

(Mushtaq et al., 2022)

Df(3R)Exel7283/Madm^4S3 is rescued by Scer\GAL4^da.G32/Madm^UAS.EGFP

(Mushtaq et al., 2022)

Madm^4S3 is rescued by Madm^UAS.cGa/Scer\GAL4^arm.PS

(Gluderer et al., 2010)

Madm^4S3 is rescued by Madm^+t5.8

(Gluderer et al., 2010)

Partially rescued by

Df(3R)Exel7283/Madm^4S3 is partially rescued by Scer\GAL4^{GluRIIB-MI03631-TG4.2}/Madm^UAS.EGFP

(Mushtaq et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Based on the severity of the pinhead phenotype, when the mutant is over Df(3R)Exel7283, the following Madm alleles can be ranked from the most severe to the weakest: Madm^2D2 = Madm^2U3 = Madm^3G5 > Madm^3Y2 = Madm^4S3 = Madm^7L2 > Madm^3T4.

(Gluderer et al., 2010)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Madm^4S3

(Mushtaq et al., 2022, Gluderer et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (2)

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