FlyBase Allele Report: Dmel\fra[6]

General Information

Symbol

Dmel\fra⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0245151

Feature type

allele

Associated gene

Dmel\fra

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with fra³)

(O'Donnell and Bashaw, 2013, O'Donnell and Bashaw, 2013)

abnormal neuroanatomy | embryonic stage (with fra³)

(Zang et al., 2022)

abnormal neuroanatomy | embryonic stage (with fra⁴)

(Chaudhari et al., 2024, Zang et al., 2022, Yang et al., 2009)

Phenotype Manifest In

axon | embryonic stage (with fra³)

(Zang et al., 2022)

axon | embryonic stage (with fra⁴)

(Zang et al., 2022)

commissure | embryonic stage (with fra³)

(Zang et al., 2022)

commissure | embryonic stage (with fra⁴)

(Chaudhari et al., 2024, Zang et al., 2022)

connective | embryonic stage (with fra³)

(Zang et al., 2022)

connective | embryonic stage (with fra⁴)

(Chaudhari et al., 2024, Zang et al., 2022)

larval EW neuron (with fra³)

(O'Donnell and Bashaw, 2013, O'Donnell and Bashaw, 2013)

larval EW neuron (with fra⁴)

(Yang et al., 2009)

larval EW neuron | embryonic stage (with fra³)

(Zang et al., 2022)

larval EW neuron | embryonic stage (with fra⁴)

(Chaudhari et al., 2024, Zang et al., 2022)

larval longitudinal connective (with fra³)

(O'Donnell and Bashaw, 2013)

larval posterior commissure (with fra³)

(O'Donnell and Bashaw, 2013)

symmetrical commissure (with fra³)

(O'Donnell and Bashaw, 2013)

Detailed Description

Statement

Reference

fra³/fra⁶ stage 15 embryos exhibit defects in EW midline axon crossing in approximately 20% of segments.

(O'Donnell and Bashaw, 2013)

EW axons in fra³/fra⁶ hypomorphic mutants fail to cross in ~20% of segments.

(O'Donnell and Bashaw, 2013)

fra⁴/fra⁶ mutant embryos have normal commissure formation and a mild EW axon crossing defect.

(Yang et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by comm[+]/comm^Δe39

(Yang et al., 2009)

NOT Enhanced by

Statement

Reference

Df(3R)BSC794, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

Suppressed by

Statement

Reference

fra⁶/fra³ has abnormal neuroanatomy phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

NOT suppressed by

Statement

Reference

Df(3R)BSC794, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has commissure | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has connective | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra³ has axon | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has axon | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has commissure | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra⁴ has axon | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has commissure | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has axon | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra⁴ has larval EW neuron phenotype, enhanceable by comm[+]/comm^Δe39

(Yang et al., 2009)

NOT Enhanced by

Statement

Reference

Df(3R)BSC794, fra⁶/fra³ has axon | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has axon | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

Suppressed by

Statement

Reference

fra⁶/fra³ has larval EW neuron phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

NOT suppressed by

Statement

Reference

Df(3R)BSC794, fra⁶/fra³ has axon | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has axon | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

An Abl¹/+ heterozygous background enhances the EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos.

An Abl²/+ heterozygous background enhances the EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos. However, the addition of Abl^{K417N.Scer\UAS} or Abl^{K417N.Scer\UAS.T:Avic\GFP} (under the control of Scer\GAL4^eg-Mz360) to these embryos reduces the percentage of segments affected with EW midline crossing defects.

An Abl⁴/+ heterozygous background increases the number of EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos. However, the addition of Abl^{K417N.Scer\UAS} or Abl^{K417N.Scer\UAS.T:Avic\GFP} (under the control of Scer\GAL4^eg-Mz360) to these embryos significantly reduces the percentage of segments affected with EW midline crossing defects.

(O'Donnell and Bashaw, 2013)

A Src64B^ko heterozygous background suppresses the EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

Co-expression of Src64B^YF.Scer\UAS under the control of Scer\GAL4^eg-Mz360 enhances the EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

An unc-5² heterozygous background does not affect the level EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

A drl^R343 homo or heterozygous background does not affect the level EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

(O'Donnell and Bashaw, 2013)

The commissural defects seen in fra⁴/fra⁶ embryos are enhanced in a heterozygous comm^E39/+ genetic background as shown by missing and thin commissures in many segments, as well as an increased frequency of non-crossing defects in a subset of of commissural neurons.

(Yang et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fra⁶

(Chaudhari et al., 2024, Zang et al., 2022, Russell et al., 2021, Hernandez-Fleming et al., 2017, O'Donnell and Bashaw, 2013, O'Donnell and Bashaw, 2013, Yang et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (7)

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